Relationship of Morphological and Mechanical Characteristics in Vertebral Trabecular Bone

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Several researchers investigated the mechanical characteristics of human trabecular bone using finite element analysis (FEA) based on micro computed tomography (μ-CT). There were few investigations on morphological and mechanical characteristics of vertebral trabecular bones. This study analyzed the relationship between morphological and mechanical characteristics in the regional vertebral trabecular bones using μ-CT and μ-FEA. Two specimens were obtained from the 12th thoracic vertebral bodies of cadavers (85 years female and 48 years male). In each vertebral body, fifteen regions were selected from two-dimensional (2D) images acquired from μ-CT. Voxelbased three-dimensional (3D) finite element models, with 444 cubic block, were generated from each region for simulated compression test. The relationship between morphological characteristics, such as bone volume fraction, trabecular thickness, trabecular separation, trabecular number and structure model index, and mechanical characteristics, such as structural modulus (E†), was analyzed by bivariate correlation coefficient. As a result, the region of center column and inferior layer had the highest density. However, structural moduli in center column and middle layer were the biggest. The results indicated that there was a regional difference between morphological and mechanical characteristics of vertebral trabecular bone. In addition, for more exact evaluation of osteoporosis, it was recommended to analyze not only the mechanical characteristics but also the morphology characteristics.

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Periodical:

Key Engineering Materials (Volumes 342-343)

Edited by:

Young-Ha Kim, Chong-Su Cho, Inn-Kyu Kang, Suk Young Kim and Oh Hyeong Kwon

Pages:

41-44

Citation:

T. W. Lee et al., "Relationship of Morphological and Mechanical Characteristics in Vertebral Trabecular Bone", Key Engineering Materials, Vols. 342-343, pp. 41-44, 2007

Online since:

July 2007

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$38.00

[1] D. Ulrich, B. van Rietbergen, H. Weinans and P. Ruegsegger: Finite element analysis of tranbecular bone structure: a comparison of image-based meshing technique. J. Biomech. Vol. 31 (1998), pp.1187-1192.

DOI: https://doi.org/10.1016/s0021-9290(98)00118-3

[2] L. Frank, H. Ivan and M. Frank: The effect of specimen geometry on the mechanical behaviors of trabucular bone specimens. J. Biomech. Vol. 25 (1992), pp.359-368.

[3] G. He, Z. Ming, Y. Hiu Yan and Q. Ling: Regional variations in microstructural properties of vertebral trabeculae with aging. J Bone Miner Metab. Vol. 23 (2005), pp.174-180.

DOI: https://doi.org/10.1007/s00774-004-0557-4

[4] S. Keller, H. Hansson, C. Anram, M. Spengler, M. Panjabi, D. Tech: Regional variations in the compressive properties of lumbar vetebral trabeculae: effects of disc degeneration. Spine J. Vol. 14 (1989), pp.1012-1019.

DOI: https://doi.org/10.1097/00007632-198909000-00016

[5] M. Ding and I. Hvid: Quantification of Age-Related changes in the Structure Model Type and Trabecular Thickness of Human Tibial Cancellous bone. Bone J. Vol. 26(3) (2000), pp.291-295.

DOI: https://doi.org/10.1016/s8756-3282(99)00281-1

[6] K. Goel, A. Ramirez, K. Weizeng and G. Gilbertson: Cancellous bone young`s modulus variation within the vertebral body of a ligamentous lumbar spin-application of bone adaptive remodeling concepts. Journal Biomech. Vol. 117 (1995), pp.117-267.

DOI: https://doi.org/10.1115/1.2794180

[7] D. Ulich, B. van Rietbergen, A. Laib and P. Ruegsegger: The ability of three-dimensional structural indices to reflect mechanical aspects of trabecular bone. Bone J. Vol. 25(1) (1999), pp.55-60.

DOI: https://doi.org/10.1016/s8756-3282(99)00098-8

[8] C. M. T Jeremy, M. S. H. Kuan, E. L. K. Justin and H. T. Keh: Relationship between CT intensity, micro-architecture and mechanical properties of porcine vertebral cancellous bone. Clin Biomech. Vol. 21 (2006), pp.235-244.

DOI: https://doi.org/10.1016/j.clinbiomech.2005.11.001

[9] D. G. Woo, H. S. Kim, Y. Y. Won, M. H. Baek and G. R. Tack: The elatstic and plastic behavior of the micro-FE models for vertebral trabecular bones. The conference of KSPE 1st (2003), p.1320~1323.

[10] B. van Rietbergen, H. Weinans, R. Huikes and A. Odgaard: Computational strategies for iterative solutions of large FEM applications employing voxel data. Int J Numer Meth Engng. Vol. 28 (1996), pp.2743-2767�.

DOI: https://doi.org/10.1002/(sici)1097-0207(19960830)39:16<2743::aid-nme974>3.0.co;2-a