Preparation and Release Profile of BDNF-Loaded PLGA/SIS Scaffold

Abstract:

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The goal of this study was to investigate release tendency of brain-derived neurotrophic factor (BDNF) from poly(L-lactide-co-glycolide) (PLGA) and small intestine submucosa (SIS) scaffold prepared by ice-leaching method. A porous scaffold consisting of PLGA and SIS as carrier of BDNF has been prepared in the presence of ice particle. SEM image of the PLGA/SIS scaffold showed an interconnected pore structure. The release behavior of BDNF loaded PLGA/SIS scaffold was examined for 4 weeks period at phosphate buffered saline (PBS, pH 7.4) at 37 oC. The sustained release of BDNF over 4 weeks was observed from the PLGA/SIS scaffold. These results indicate that the sustained release of BDNF from PLGA/SIS scaffold can be very useful for application in the tissue engineering.

Info:

Periodical:

Key Engineering Materials (Volumes 342-343)

Edited by:

Young-Ha Kim, Chong-Su Cho, Inn-Kyu Kang, Suk Young Kim and Oh Hyeong Kwon

Pages:

413-416

DOI:

10.4028/www.scientific.net/KEM.342-343.413

Citation:

Y. N. Shin et al., "Preparation and Release Profile of BDNF-Loaded PLGA/SIS Scaffold", Key Engineering Materials, Vols. 342-343, pp. 413-416, 2007

Online since:

July 2007

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Price:

$38.00

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