Aqueous Solubilization of Paclitaxel Using Hydrotropic Polymer Micelle


Article Preview

Hydrotropic block copolymers, consisting of a hydrophilic poly(ethylene glycol) (PEG) block and a hydrotropic polymer, poly(2-(4-(vinyl benzyloxy)-N,N-diethylnicotinamide)) [P(VBODENA)], block, were synthesized by atom transfer radical polymerization (ATRP) for aqueous solubilization of paclitaxel, a representative poorly water-soluble drug. These polymers showed an excellent solubilizing effect for paclitaxel in aqueous media in comparison with the corresponding hydrotropic agent and a control micelle (PEG-PLA) and such effect was significantly dependent on the polymer concentration and composition. Paclitaxel could be solubilized into polymer micelles in aqueous media without use of an organic solvent. Due to their promising properties such as micellar characteristics and hydrotropic solubilization, the hydrotropic polymer micelle system can be useful for formulation of paclitaxel and other poorly soluble drugs.



Key Engineering Materials (Volumes 342-343)

Edited by:

Young-Ha Kim, Chong-Su Cho, Inn-Kyu Kang, Suk Young Kim and Oh Hyeong Kwon




H. S. Min et al., "Aqueous Solubilization of Paclitaxel Using Hydrotropic Polymer Micelle", Key Engineering Materials, Vols. 342-343, pp. 421-424, 2007

Online since:

July 2007




[1] P.B. Myrdal, S.H. Yalcowsky, in: Encyclopedia of pharmaceutical Technology, Edited by J. Swarbrick, J.C. Boylan, Marcel Dekker (2002).

[2] R. Paradis, M. page: Anticancer release, Vol. 18 (1998), pp.2711-2716.

[3] J. Lee, S.C. Lee, G. Acharya, C. Chang and K. Park: Pharm Res. Vol. 20 (2003), pp.1022-1030.

[4] V.S. Trubetskoy: Adv. Drug Deliv. Rev. Vol. 37 (1999), pp.81-88.

[5] K.M. Huh, S.C. Lee, Y.W. Cho, J. Lee, K. Park: J. Control. Release Vol. 101 (2005), pp.59-68.

[6] G. Gaucher, M.H. Dufresne, V.P. Sant, N. Kang, D. Maysinger, J.C. Leroux: J. Control. Release Vol. 109 (2005), pp.169-188.

[7] S.C. Lee, G. Acharya, J. Lee, K. Park: Macromolecules Vol. 36 (2003), pp.2248-2255.

[8] Y.W. Cho, J. Lee, S.C. Lee, K.M. Huh, K. Park: J. Control. Release Vol. 97 (2004), pp.249-257.

[9] K. Matyjaszewski, J. Xia: Chem Rev. Vol. 101 (2001), pp.2921-2990.

[10] H.M. Burt, X. Zhang, P. Toleikis, L. Embree, W.L. Hunter: Colloids Surf., B Biointerfaces Vol. 16 (1999), pp.161-171 Figure 4. Release kinetics of paclitaxel from PEG5000P(VBODENA)7000 micelles in 0. 8 M sodium salicylate solution at 37�o C.