Thiolated Eudragit-Coated Chitosan Microspheres as an Oral Drug Delivery System

Abstract:

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The aim of this study is to prepare mucoadhesive chitosan microspheres for protein drug to deliver to intestine through oral administration. The thiolated Eudragit was synthesized by reaction between L-cysteine hydrochloride and Eudragit® L-100. About 8 mol-% of cysteine was introduced to the Eudragit-cysteine conjugate. The conjugate was used to coat bovine serum albumin (BSA)-loaded chitosan microspheres. The average particle sizes of BSA-loaded thiolated Eudragit-coated chitsoan microspheres (TECMs) were 4.06±0.74 .m and the uniform sizedistribution was shown. The in vitro release of BSA from BSA-loaded TECMs was pH-dependent. Our results indicated that thiolated Eudragit might be a good candidate as a coating material for oral delivery of protein drug owing to mucoadhesive and pH-sensitive properties.

Info:

Periodical:

Key Engineering Materials (Volumes 342-343)

Edited by:

Young-Ha Kim, Chong-Su Cho, Inn-Kyu Kang, Suk Young Kim and Oh Hyeong Kwon

Pages:

445-448

DOI:

10.4028/www.scientific.net/KEM.342-343.445

Citation:

J. S. Quan et al., "Thiolated Eudragit-Coated Chitosan Microspheres as an Oral Drug Delivery System", Key Engineering Materials, Vols. 342-343, pp. 445-448, 2007

Online since:

July 2007

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Price:

$35.00

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