Preparation and Characterization of Porous Membrane for Drug Release


Article Preview

To develop osmotic granule with semi-permeable membranes, we prepared the semipermeable membranes with different pore forming agent by using solvent casting method. The membrane was consisted of cellulose acetate, Eudragit® RS, hydroxypropylcellulose (HPC), and triethylcitrate (TEC) in the presence of PEG200, PEG1, 000, or dibutylsebacate(DBS) as a pore forming agent. The produced membranes were white and elastic and exhibited soft property on touch. The release amount of pore forming agent from membrane with different pore forming agent was measured in water dissolution media and the order was PEG200 > PEG1, 000 > DBS. The formation of pore in membrane was observed by morphological SEM image after dissolution. The pore formation and porosity of membrane depended on water solubility of pore forming agent. We confirmed that pores in porous semi-permeable membrane could be controlled by the pore forming agent.



Key Engineering Materials (Volumes 342-343)

Edited by:

Young-Ha Kim, Chong-Su Cho, Inn-Kyu Kang, Suk Young Kim and Oh Hyeong Kwon




S. Y. Lee et al., "Preparation and Characterization of Porous Membrane for Drug Release", Key Engineering Materials, Vols. 342-343, pp. 485-488, 2007

Online since:

July 2007




[1] S. N. Makhija, P. R. Vavia, Controlled porosity osmotic pump-based controlled release systems of pseudoephedrine, J Control Release 89, 5 (2003).


[2] S. B. Jung, G. D. Kang, J. Y. Huh, S. Ahn, E. C. Monge, G. Khang, S. C. Song, Thermosensitive Biodegradable Poly(organophosphazene) Gels and Their Blends, Tissue Eng Regen Medicine 3, 108 (2006).

[3] S. C. Jeong, Y. H. Cho, The Effects of Osmogant and Binder in Membrane on Nifedipine Release from Osmotic Granule, Polymer(Korea), 30, 112 (2006).

[4] S. M. Herbig, J. R. Cardinal, R. W. Korsmeyer, K. L Smith, Asymmetric membrane tablet coating for osmotic drug delivery, J Control Release 35, 127 (1995).


[5] J. Fujimori, Y. Yoshihashi, E. Yonemochi, K. Terada, Application of Eudragit RS to thermosensitive drug delivery systems, J Control Release 102, 49 (2005).


[6] M. M. Meier, L. A. Kanis, V. Soldi, Characterization and drug-permeation profiles of microporous and dense cellulose acetate membranes, Int J Pharm 278, 99 (2004).


[7] S. Yamane, K. Takayama, T. Nagai, Effect of fractal dimension on drug permeation through porous ethylcellulose film, J Control Release 50, 103 (1998).