A Novel Degradation Controlled Hyaluronic Acid Derivatives

Abstract:

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A novel protocol to control the molecular degradation of hyaluronic acid (HA) was successfully developed. HA has a different conformational structure in water and in organic solvent, and the carboxyl group of HA is known to be the recognition site of CD44 and hyaluronidase. Based on these facts, HA was chemically modified in the mixed solvent of water and ethanol by grafting adipic acid dihydrazide (ADH) to the carboxyl group of HA, which resulted in high degree of ADH modification up to 85 mol% with controlled degradation of HA by hyaluronidase. The degradation controlled HA-ADH will be assessed for various tissue engineering applications.

Info:

Periodical:

Key Engineering Materials (Volumes 342-343)

Edited by:

Young-Ha Kim, Chong-Su Cho, Inn-Kyu Kang, Suk Young Kim and Oh Hyeong Kwon

Pages:

525-528

Citation:

E. J. Oh et al., "A Novel Degradation Controlled Hyaluronic Acid Derivatives", Key Engineering Materials, Vols. 342-343, pp. 525-528, 2007

Online since:

July 2007

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$38.00

[1] T.C. Laurent: The Chemistry, Biology and Medical Applications of Hyaluronan and its Derivatives (Portland Press, London 1998).

[2] C. Picart, P. Lavalle, P. Hubert, F.J.G. Cuisiniear, G. Decher, P. Schaaf and J.C. Voegel: Langmuir, Vol. 17 (2001), p.7414.

[3] E.A. Balazs and J.L. Denlinger: J. Rheumatology, Vol. 20 (1993), p.3.

[4] E.A. Balazs, in: Healon (sodium hyaluronate). A guide to its use in ophthalmic surgery, edited by D. Miller and R. Stegmann/Wiley, New York (1983).

[5] K.P. Vercruysse and G.D. Prestwich: Crit. Rev. Therapeut. Carrier Sys. Vol. 15 (1998), p.513.

[6] D.C. West, I.N. Hampson, F. Arnold and S. Kumar: Science, Vol. 228 (1985), p.1324.

[7] D. Campoccia, P. Doherty, M. Radice, P. Brun, G. Abatangelo and D.F. Williams: Biomaterials, Vol. 19 (1998), p.2101.

[8] T. Pouyani and G.D. Prestwich: Bioconj. Chem. Vol. 5 (1994), p.339.

[9] E.A. Balazs and A. Leshchiner, U.S. patent 4, 582, 865. (1986).

[10] E.A. Balazs and A. Leshchiner, U.S. patent 4, 713, 448. (1987).

[11] Y. Luo, K. Kirker and G.D. Prestwich: J. Cont. Rel. Vol. 69 (2000), p.169 (A) (B) (C).