Development of Micro-Patterned 2.5-D Scaffold Using Micro-End-Milling
We fabricated micro-patterned 2.5-D scaffolds using micro-end-milling with controlled pore and island sizes and interconnectivity to determine the effects of the micro-patterns on the cell culturing process. Micro-end-milling can easily realize a high aspect ratio and accuracy, and can be applied to various materials, including those that are biocompatible and biodegradable. Sixteen types of micro-patterned scaffolds were designed and fabricated using the micro-end-milling process. Fibroblasts were seeded and cultured to examine the viability of the developed micropatterned scaffolds and their absorbed cell adhesion. The results confirmed that the fabricated micro-patterns functioned successfully as scaffolds.
Young-Ha Kim, Chong-Su Cho, Inn-Kyu Kang, Suk Young Kim and Oh Hyeong Kwon
H. U. Lee et al., "Development of Micro-Patterned 2.5-D Scaffold Using Micro-End-Milling", Key Engineering Materials, Vols. 342-343, pp. 53-56, 2007