Zirconia was introduced into the dentistry as a metal-replacement material because of its outstanding mechanical properties like high flexural strength and fracture toughness. The purpose of this study was to evaluate bone response and examine the surface characteristics of zirconiabased implant. Screw shaped c.p. titanium implants(group 1), HA-based composite implants(group 2), HA/FA coated ZrO2 implants(group 3) and FA coated ZrO2 implants(group 4) were installed in rabbit tibias. After 4 and 12 weeks of healing period, the histomorphometric analysis was performed with an Olympus BX microscope connected to a computer. The percentage of bone-to-implant contact in the 3 best consecutive threads and the percentage of bone inside the same threads were calculated. the present study demonstrated the excellent bone response of ZrO2-based implants fabricated by various methods to combine the advantages of ZrO2, HA, and FA.