Study of Biodegradation of Pure Magnesium

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Magnesium and its alloys are possible to develop new type of biodegradable medical magnesium alloys by using their active corrosion potential. The bio-corrosion properties of the high pure magnesium in the Hank’s solution were investigated in this paper, the results showed that high pure magnesium had a low corrosion rate and hydrogen release in Hank’s solution, when the pH value of solution was controlled at 7.5, the corrosion rate was under 0.2mm/year, the production of hydrogen was about 0.15ml/cm2, and if the solution wasn’t controlled on pH value, the corrosion rate was about 0.02 mm/year, production of hydrogen was about 0.1ml/cm2 . Result of in vitro Kinetic clotting time test and animal implant prep-test showed that High pure magnesium had good thromboresistant property and tissue compatibility, pure magnesium can biodegrade lowly in animal body and formed surface apatite, which proportion of Ca/P was similar with bone tissue.

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Periodical:

Key Engineering Materials (Volumes 342-343)

Edited by:

Young-Ha Kim, Chong-Su Cho, Inn-Kyu Kang, Suk Young Kim and Oh Hyeong Kwon

Pages:

601-604

Citation:

Y. B. Ren et al., "Study of Biodegradation of Pure Magnesium", Key Engineering Materials, Vols. 342-343, pp. 601-604, 2007

Online since:

July 2007

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Price:

$38.00

[1] Information on http: / www. hasylab. desy. de/science/annual_reports/2001_report/part1/contrib/ 47/5461. pdf.

[2] Stroganov GB, Savitsky E, Mikhailovich T, et al, U.S. Patent 3, 687, 135 (1972).

[3] McBride ED: J Am Med Assoc. Vol. 111(1938), pp.2464-7.

[4] Witte F, Kaese V, Haferkamp H, Switzer E, et al: Biomaterials Vol. 26(2005), pp.3557-63.

[5] Carlo Di Mario, Huw Grifftths, Omer Goktekin, et al: Journal of interventional cardiology. Vol. 17 (2004), pp.391-395.

[6] B Heublein, R Rohde, V Kaese, M Niemeyer, W Hartung, A Haverich: Heart, Vol. 89 (2003), p.651.

[7] Ren Yb, Huang Jj, Yang K, et al: Acta Metallurgica Sinica. Vol. 41 (2005), pp.1228-1232, in Chinese.

[8] Kuwahara H, Al-Abdullat Y, Mazaki N, et al: Mater Trans Vol. 42 (2001), p.1317�21.

[9] D Y Wang, F Liu, J H Li, et al: Journal of Biomedical Engineering Vol. 19 (2002), p.17, In Chinese.

[10] Yu YT, Zhang XD: Biomedical Materials (TianJin university press, TianJin 2000), in Chinese. 0. 5mm 1. 5mm Pure Mg bone Fig. 5 SEM photograph of a cross-section of the rabbit femur bone implanted with magnesium after 7 days. Fig. 6 EDS qualitative analysis of element in surface film of the Mg after being implanted into the rabbit femur for 7 days.