Ca-P Formation on Poly-L-Lactide/β-Tricalcium Phosphate Composite Scaffold in Simulated Body Fluid

Abstract:

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Poly-L-lactide/β-tricalcium phosphate (PLLA/β-TCP) porous scaffold fabricated by freeze shrinking/particulate leaching was studied. The scaffold was immersed into simulated body fluid (SBF) for 1, 2, 3 and 4 weeks and analyzed by the SEM, XRD and FT-IR spectroscopy. The ability of inducing Ca-P formation was compared among the scaffolds with different content of β- TCP. SEM shows a typical feature of apatite precipitation. Diffraction peak of new crystal structure was detected by x-ray diffraction (XRD). IR Spectrum in which absorption bands arise from newly formed groups of carbonate apatite can be seen. At the same testing point, higher density of Ca-P crystal can be observed by SEM in scaffold with high content of β-TCP than in low group. Until 3 weeks, Ca-P individual crystal started on the wall of inner pore of pure PLLA. Porous PLLA/β-TCP composite scaffolds also indicate good ability of Ca-P formation in vitro, the ability of which to form apatite was enhanced by addition of each other that has different degradable mechanism.

Info:

Periodical:

Key Engineering Materials (Volumes 342-343)

Edited by:

Young-Ha Kim, Chong-Su Cho, Inn-Kyu Kang, Suk Young Kim and Oh Hyeong Kwon

Pages:

689-692

DOI:

10.4028/www.scientific.net/KEM.342-343.689

Citation:

Y. Q. Kang et al., "Ca-P Formation on Poly-L-Lactide/β-Tricalcium Phosphate Composite Scaffold in Simulated Body Fluid", Key Engineering Materials, Vols. 342-343, pp. 689-692, 2007

Online since:

July 2007

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Price:

$35.00

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