Ca-P Formation on Poly-L-Lactide/β-Tricalcium Phosphate Composite Scaffold in Simulated Body Fluid


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Poly-L-lactide/β-tricalcium phosphate (PLLA/β-TCP) porous scaffold fabricated by freeze shrinking/particulate leaching was studied. The scaffold was immersed into simulated body fluid (SBF) for 1, 2, 3 and 4 weeks and analyzed by the SEM, XRD and FT-IR spectroscopy. The ability of inducing Ca-P formation was compared among the scaffolds with different content of β- TCP. SEM shows a typical feature of apatite precipitation. Diffraction peak of new crystal structure was detected by x-ray diffraction (XRD). IR Spectrum in which absorption bands arise from newly formed groups of carbonate apatite can be seen. At the same testing point, higher density of Ca-P crystal can be observed by SEM in scaffold with high content of β-TCP than in low group. Until 3 weeks, Ca-P individual crystal started on the wall of inner pore of pure PLLA. Porous PLLA/β-TCP composite scaffolds also indicate good ability of Ca-P formation in vitro, the ability of which to form apatite was enhanced by addition of each other that has different degradable mechanism.



Key Engineering Materials (Volumes 342-343)

Edited by:

Young-Ha Kim, Chong-Su Cho, Inn-Kyu Kang, Suk Young Kim and Oh Hyeong Kwon




Y. Q. Kang et al., "Ca-P Formation on Poly-L-Lactide/β-Tricalcium Phosphate Composite Scaffold in Simulated Body Fluid", Key Engineering Materials, Vols. 342-343, pp. 689-692, 2007

Online since:

July 2007




[1] Tadashi Kokubo and Hiroaki Takadama: Biomaterials Vol. 27 (2006), p.2907.

[2] Renlong Xina, Yang Lenga and Jiyong Chenb: Biomaterials Vol. 26 (2005), p.6477.

[3] Filgueiras MR, Torre GL and Hench LL: J Biomed. Mat. Res. Vol. 27 (1993), p.445.

[4] Yang Leng, Jiyong Chen and Shuxin Qu: Biomaterials Vol. 24 (2003), p.2125.

[5] Ohtsuki C, Kokubo T and Neo M: Phos. Res. Bull. Vol. 1 (1991), p.191.

[6] Ohtsuki C, Aoki Y and Kokubo T:. Transactions of the 11th annual meeting of Japanese Society for Biomaterials, 1989. p.12.

[7] Ducheyne P, Kokubo T and van Blitterswijk CA, editors. Bone bonding biomaterials. Leiderdrop: Reed Healthcare Communication; 1992, p.13.

[8] Kai Zhang, Yunbing Wang and M.A. Hillmyer: Biomaterials Vol. 25 (2004), p.2489.

[9] M. Wang and L.J. Chen: J Mat. Sci.: Mat. in Med. Vol. 12 (2001), p.855.

[10] V. Andre-Frei, B. Chevallay and Orly: Calcif. Tissue Int., 66 (2000), p.204.