Star-Shaped Poly (Γ-Caprolactone-b-Ethylene Glycol): Synthesis, Characterization and Aggregation Behavior

Abstract:

Article Preview

Linear and Star-shaped PCL-b-PEG copolymers were synthesized through a two step process, including the first step to synthesize the star-shaped PCL through ring-opening polymerization of Γ-caprolactone initiated from multi-functional alcohol under the existence of tin(II) ethylhexanoate [Sn(Oct)2] catalyst, and the following step to couple the obtained star-shaped PCL with PEG segments using bi-functional linker. The structure of the polymers was confirmed by IR, NMR, GPC, et al. The aggregation behaviors of the star-shape copolymers were compared with that of the linear block copolymer with corresponding molecular weight of each arm, and the influences of structure factors were discussed.

Info:

Periodical:

Key Engineering Materials (Volumes 342-343)

Edited by:

Young-Ha Kim, Chong-Su Cho, Inn-Kyu Kang, Suk Young Kim and Oh Hyeong Kwon

Pages:

725-728

Citation:

Y. J. Fan et al., "Star-Shaped Poly (Γ-Caprolactone-b-Ethylene Glycol): Synthesis, Characterization and Aggregation Behavior", Key Engineering Materials, Vols. 342-343, pp. 725-728, 2007

Online since:

July 2007

Export:

Price:

$38.00

[1] Kumar, N.; Ravikumar, M. N.; Domb, A. J., Biodegradable block copolymers. Adv Drug Deliv Rev 2001, 53, (1), 23-44.

DOI: https://doi.org/10.1016/s0169-409x(01)00219-8

[2] Kataoka, K.; Harada, A.; Nagasaki, Y., Block copolymer micelles for drug delivery: design, characterization and biological significance. Adv Drug Deliv Rev 2001, 47, (1), 113-31.

DOI: https://doi.org/10.1016/s0169-409x(00)00124-1

[3] Duncan, R., The dawning era of polymer therapeutics. Nat Rev Drug Discov 2003, 2, (5), 347-60.

DOI: https://doi.org/10.1038/nrd1088

[4] Shuai, X.; Ai, H.; Nasongkla, N.; Kim, S.; Gao, J., Micellar carriers based on block copolymers of poly(epsilon-caprolactone) and poly(ethylene glycol) for doxorubicin delivery. J Control Release 2004, 98, (3), 415-26.

DOI: https://doi.org/10.1016/j.jconrel.2004.06.003

[5] Piskin; Kaitian, X.; Denkbas, E. B.; Kucukyavuz, Z., Novel PDLLA/PEG copolymer micelles as drug carriers. J Biomater Sci Polym Ed 1995, 7, (4), 359-73.

DOI: https://doi.org/10.1163/156856295x00373

[6] Kim, S. Y.; Shin, I. G.; Lee, Y. M., Amphiphilic diblock copolymeric nanospheres composed of methoxy poly(ethylene glycol) and glycolide: properties, cytotoxicity and drug release behaviour. Biomaterials 1999, 20, (11), 1033-42.

DOI: https://doi.org/10.1016/s0142-9612(98)00249-x

[7] Letchford, K.; Zastre, J.; Liggins, R.; Burt, H., Synthesis and micellar characterization of short block length methoxy poly(ethylene glycol)-block-poly(caprolactone) diblock copolymers. Colloids Surf B Biointerfaces 2004, 35, (2), 81-91.

DOI: https://doi.org/10.1016/j.colsurfb.2004.02.012

[8] Lin, W. J.; Chen, Y. C.; Lin, C. C.; Chen, C. F.; Chen, J. W., Characterization of pegylated copolymeric micelles and in vivo pharmacokinetics and biodistribution studies. J Biomed Mater Res B Appl Biomater 2006, 77, (1), 188-94.

DOI: https://doi.org/10.1002/jbm.b.30418

[9] Kricheldorf, H. R. S., I. K.; Boettcher, C. , Polylactones: 31. Sn(II)octoate-initiated polymerization of L-lactide: a mechanistic study. Polymer 1995, 36, (6), 1253.

DOI: https://doi.org/10.1016/0032-3861(95)93928-f

[10] Yujiang Fan, G. C., Junzo Tanaka, and Tetsuya Tateishi, L-Phe End Capped Poly(L, L-lactide) as Macro Initiator for the Synthesis of Poly(L, L-lactide)-b-poly(L-lysine) Block Copolymer. Biomacromolecules (2005).

DOI: https://doi.org/10.1021/bm050368u