Antibacterial Polyurethane Organosilicate Nanocomposites


Article Preview

Thermoplastic polyurethanes are versatile polymers much used for biomedical applications due to their mechanical properties and biocompatibility. Like most implantable materials they are susceptible to bacterial colonization, particularly in applications at high risk of bacterial contamination such as percutaneous catheters. The objective of this study was to assess the antibacterial activity and the cell responses to a series of nanocomposite variants fabricated from a polyether polyurethane and organically modified silicates containing either antibacterial dispersing agents, non-antibacterial dispersing agents, or combinations of the two. The results suggest that co-modification is a promising approach for modulating both bacterial and mammalian cell responses to achieve appropriate antibacterial properties without cell inhibition.



Key Engineering Materials (Volumes 342-343)

Edited by:

Young-Ha Kim, Chong-Su Cho, Inn-Kyu Kang, Suk Young Kim and Oh Hyeong Kwon




K. Styan et al., "Antibacterial Polyurethane Organosilicate Nanocomposites", Key Engineering Materials, Vols. 342-343, pp. 757-760, 2007

Online since:

July 2007




[1] R. O. Darouiche: N. Engl. J. Med. Vol. 350 (2004), p.1422.

[2] L. B. Rice: Biochemical Pharmacology Vol. 71 (2006), p.991.

[3] R. O. Darouiche et al.: Ann. Surg. Vol. 242 (2005), p.193.

[4] M. E Rupp et al.: Ann. Intern. Med. Vol. 143 (2005), p.570.

[5] A. Han et al. : J. Appl. Pol. Sci. Vol. 91(2004), p.2536.