Effect of Inorganic Ions on Morphology and Crystallinity of Collagen Fibrils


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As a natural biomaterial, collagen especially pepsin-solubilized collagen (type I) has been used widely in biomedical fields due to its excellent biocompatibility. In this preliminary study, we investigate the effect of some inorganic ions which are frequently utilized in the preparation of collagen on the morphology and crystallinity of fibrils. The scanning electron microscope and x-ray diffraction were applied to analyze the morphology and the crystallization of the reconstituted collagen fibrils, respectively. Although further studies are needed, these initial results indicate that by controlling the self-assembly conditions of collagen molecules, we may achieve the desired properties of fibrillar collagen products.



Key Engineering Materials (Volumes 342-343)

Edited by:

Young-Ha Kim, Chong-Su Cho, Inn-Kyu Kang, Suk Young Kim and Oh Hyeong Kwon




Q. R. Wei et al., "Effect of Inorganic Ions on Morphology and Crystallinity of Collagen Fibrils", Key Engineering Materials, Vols. 342-343, pp. 929-932, 2007

Online since:

July 2007




[1] Kt H. Stenzel, T. Miyata, and At.L. Rubin: Annu. Rev. Biophys. Bioeng. Vol. 3 (1974), p.231.

[2] J.M. Mcpherson: Collagen Related Research Vol. 5 (1985), p.119.

[3] D.J. Prockop and A. Fertala: Journal of Structural Biology Vol. 122 (1998), p.111.

[4] K.I. Clarke, S.E. Graves, and A.T. C Wong: J. Mater. Sci. -Mater. Med. Vol. 4 (1993), p.107.

[5] E.J. Miller: Biochemistry Vol. 11 (1972), p.119.

[6] P.K. OuYang and Y.H. Hu: Principle and Technology of biology Separation (Chemistry Industry Publications, Beijing 2004).

[7] Regina Komsa-Penkova, Rumiana Koynova, and Georgi Kostov: Biochimica Biophysica Acta. Vol. 1297 (1996), p.171.

DOI: https://doi.org/10.1016/s0167-4838(96)00092-1

[8] K.D. Collins and M.W. W ashabaugh: Q. Rev. Biophys. Vol. 18 (1985), p.323.

[9] B.R. William, R.A. Gelman, and D.C. Poppke: J. Biol. Chem. Vol. 253 (1978), p.6578.

[10] G.C. Na, l. j. Phillips, and B. Brodsky: Biochemistry Vol. 28 (1989), p.7153.

[11] J.M. Mcpherson: Collagen Related Research Vol. 5 (1985), p.119.