Growth of Smooth Muscle Cell and Endothelial Cell on PLGA Film Containing EGCG


Article Preview

Poly (D,L-latic-co-glycolic acid) (PLGA) has been used as the artificial scaffold for blood vessel formation. In order to hinder smooth muscle cell (SMC) angiogenesis, new scaffold design method of loading Epigallocatechin 3-O-gallate (EGCG) on PLGA film was introduced. PLGA and EGCG were dissolved in acetone and film-shape scaffold was manufactured. Antiangiogenetic effect of EGCG released on scaffold was analyzed for SMC and human umbilical vein endothelial cell (HUVEC) and method for selective inhibition from the difference of growth of SMC and HUVEC was suggested.



Key Engineering Materials (Volumes 342-343)

Edited by:

Young-Ha Kim, Chong-Su Cho, Inn-Kyu Kang, Suk Young Kim and Oh Hyeong Kwon




J. H. Chung et al., "Growth of Smooth Muscle Cell and Endothelial Cell on PLGA Film Containing EGCG", Key Engineering Materials, Vols. 342-343, pp. 93-96, 2007

Online since:

July 2007




[1] A. Armulik, A. Abramsson and C. Betsholtz: Circ Res 97(6) (2005), p.512~523.

[2] R.K. Jane, P. Au, J. Tam, D.G. Duda and D. Fukumura: Nat Biotechnol 23(7) (2005), p.821~823.

[3] A.K. Singh, P. Seth, P. Anthony, M.M. Husain, S. Madhavan, H. Mukhtar and R.K. Maheshwari: Arch Biochem Biophys 401(1) (2002), p.29~37.

[4] C.S. Hofmann and G. E Sonenshein: FASEB J 17(6) (2003), p.702~704.

[5] S.K. Rodriguez, W. Guo, M.A. Band, E.K. Paulson and M. Meydani: Int J Cancer 118(7) (2006), p.1635~1644.