Tests on shaking table have been carried out on a 3D full scale infilled r.c. frame specimen (55 tons). These tests have been performed by the EMSI Laboratory of C.E.A. Saclay (France) together with a research team of the Universities of Chieti-Pescara (Italy), Roma Tre (Italy) and Patras (Greece). These tests are included in Ecoleader European research program. Many characterization tests of infill components (mortar and bricks) have been performed in the SCAM Laboratory of the University of Chieti-Pescara while tests on masonry walls were made in the laboratory of University of Rome 3. The structure represents the first floor of a two floors frame structure previously tested. The mockup is a full-scale one storey rc infilled frame with four columns, 3 meters high, with about 4 meters side square floor and infilled with double bricks wall. The main aim is to get information about the behavior of real structures. The instrumentation with about one hundred channels was set up to measure the rc frame response and the different behavior of the double walls during the tests. First, monodirectional and bidirectional tests at low seismic intensity (0.10 g and 0.15 g PGA levels) have been performed on the bare frame in order to characterize its structural characteristics and to check the design provisions. Then, the bare frame has been infilled and other tests have carried out at increasing seismic intensity in order to define its serviceability and ultimate limit states. Monodirectional and bidirectional tests up to 0.45 g PGA level were carried out. The last sequence included a monodirectional test on the infilled frame with only two walls. The high seismic input (0.55 g PGA level) was parallel to the direction of the walls. In this paper, research program and some main test results are presented.