In this paper, transient dynamic crack analysis in two-dimensional, layered, anisotropic and linear elastic solids is presented. For this purpose, a time-domain boundary element method (BEM) is developed. The homogeneous and anisotropic layers are modeled by the multi-domain BEM formulation. Time-domain elastodynamic fundamental solutions for linear elastic and anisotropic solids are applied in the present BEM. The spatial discretization of the boundary integral equations is performed by a Galerkin-method while a collocation method is implemented for the temporal discretization of the arising convolution integrals. An explicit time-stepping scheme is developed to compute the discrete boundary data and the crack-opening-displacements (CODs). To show the effects of the material anisotropy and the dynamic loading on the dynamic stress intensity factors, numerical examples are presented and discussed.