Hydroxyapatite is a kind of ideal biomaterials for bone and teeth replacement, but its low strength and brittleness need to improve. As bone replacing materials, hydroxyapatite (HAP) and zirconia both have advantage and disadvantage. Nano-sized HAP-ZrO2 powders and HAP-TZP (3Y) (3mol% yttria - stabilized cubic zirconia) bioceramic for artificial joint have been fabricated in this paper. The nano-sized HAP-ZrO2 powders with homogeneous distribution could be synthesized by two-step precipitation method. The HAP-TZP bioceramic with small grain size could be obtained by using hot-press sintering technology, and the sintering parameters are: sintering temperatures T=1300°C, sintering pressure p=30MPa and sintering time t=30min. The mechanical properties, microstructures and fracture pattern that were analyzed by SEM and optical microscopy of the HAP-TZP bioceramic were investigated systematically. The results show that no reaction between HAP and ZrO2 powders, which could be attributed to the very short sintering time of hot press sintering.