In Vivo and In Vitro Response to a Gelatin/α-Tricalcium Phosphate Bone Cement


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We recently developed a new biomimetic calcium phosphate bone cement enriched with gelatin (GEL-CP) which exhibits improved mechanical properties with respect to the control cement (C-CP) and a good response to osteoblast-like cells. In this work, we have extended the investigation to primary culture of osteoblasts derived from normal (N-OB) and osteopenic (O-OB) sheep bones cultured on samples of GEL-CP, and their behavior was compared to that of cells cultured on C-CP as control. Cell morphology, proliferation, and differentiation were evaluated at 3 and 7 days. Preliminary in vivo tests were carried out onto critical size defects in the radius diaphysis of rats.



Key Engineering Materials (Volumes 361-363)

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Edited by:

Guy Daculsi and Pierre Layrolle




B. Bracci et al., "In Vivo and In Vitro Response to a Gelatin/α-Tricalcium Phosphate Bone Cement", Key Engineering Materials, Vols. 361-363, pp. 1001-1004, 2008

Online since:

November 2007




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