In Vivo and In Vitro Response to a Gelatin/α-Tricalcium Phosphate Bone Cement
We recently developed a new biomimetic calcium phosphate bone cement enriched with gelatin (GEL-CP) which exhibits improved mechanical properties with respect to the control cement (C-CP) and a good response to osteoblast-like cells. In this work, we have extended the investigation to primary culture of osteoblasts derived from normal (N-OB) and osteopenic (O-OB) sheep bones cultured on samples of GEL-CP, and their behavior was compared to that of cells cultured on C-CP as control. Cell morphology, proliferation, and differentiation were evaluated at 3 and 7 days. Preliminary in vivo tests were carried out onto critical size defects in the radius diaphysis of rats.
Guy Daculsi and Pierre Layrolle
B. Bracci et al., "In Vivo and In Vitro Response to a Gelatin/α-Tricalcium Phosphate Bone Cement", Key Engineering Materials, Vols. 361-363, pp. 1001-1004, 2008