EP4 Agonist Accelerates Osteoinduction and Degradation of β-Tricalcium Phosphate in Canine Model


Article Preview

Several kinds of biomaterials are known to possess osteoinductive ability without bone inductive substances in ectopic implantation. β-TCP is one such material that has been reported to exhibit this ability in a canine model. In addition, prostaglandin E2 has been proved to accelerate osteogenesis in a rodent model, and one of its receptors EP4 has been considered to play a particularly important role. We examined that the EP4 agonist accelerates β-TCP-induced osteoinduction in a canine model. The results suggested that the EP4 agonist accelerated not only osteoinduction but also osteoclastogenesis prior to bone formation.



Key Engineering Materials (Volumes 361-363)

Main Theme:

Edited by:

Guy Daculsi and Pierre Layrolle




T. Nasu et al., "EP4 Agonist Accelerates Osteoinduction and Degradation of β-Tricalcium Phosphate in Canine Model", Key Engineering Materials, Vols. 361-363, pp. 1021-1024, 2008

Online since:

November 2007




[1] Fujibayashi S, Neo M, Kim HM, Kokubo T, Nakamura T.: Biomaterials. 25(3) (2004), pp.443-450.

[2] Takemoto M, Fujibayashi S, Neo M, Suzuki J, Matsushita T, Kokubo T, et al.: Biomaterials. 27(13) (2006), pp.2682-2691.

DOI: https://doi.org/10.1016/j.biomaterials.2005.12.014

[3] Kondo N, Ogose A, Tokunaga K, Umezu H, Arai K, Kudo N, et al.: Biomaterials. 27 (25) (2006), pp.4419-4427.

[4] Sakuma Y, Tanaka K, Suda M, Yasoda A, Natsui K, Tanaka I, et al.: J Bone Miner Res. 15 (2) (2000), pp.218-227.

[5] Mano M, Arakawa T, Mano H, Nakagawa M, Kaneda T, Kaneko H, et al.: Calcif Tissue Int. 67 (1) (2000), pp.85-92.

[6] Take I, Kobayashi Y, Yamamoto Y, Tsuboi H, Ochi T, Uematsu S, et al.: Endocrinology. 146 (12) (2005), pp.5204-5214.

[7] Narumiya S, Sugimoto Y, Ushikubi F.: Physiol Rev. 79 (4) (1999), pp.1193-1226.

[8] Sasaoka R, Terai H, Toyoda H, Imai Y, Sugama R, Takaoka K.: Biochem Biophys Res Commun. 318 (3) (2004), pp.704-709.

[9] Kanzaki H, Chiba M, Shimizu Y, Mitani H.: J Bone Miner Res. 17 (2) (2002), pp.210-220.

[10] Ogata S, Kubota Y, Satoh S, Ito S, Takeuchi H, Ashizuka M, et al.: Biochem Biophys Res Commun. 351 (4) (2006), pp.808-814.