EP4 Agonist Accelerates Osteoinduction and Degradation of β-Tricalcium Phosphate in Canine Model

Abstract:

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Several kinds of biomaterials are known to possess osteoinductive ability without bone inductive substances in ectopic implantation. β-TCP is one such material that has been reported to exhibit this ability in a canine model. In addition, prostaglandin E2 has been proved to accelerate osteogenesis in a rodent model, and one of its receptors EP4 has been considered to play a particularly important role. We examined that the EP4 agonist accelerates β-TCP-induced osteoinduction in a canine model. The results suggested that the EP4 agonist accelerated not only osteoinduction but also osteoclastogenesis prior to bone formation.

Info:

Periodical:

Key Engineering Materials (Volumes 361-363)

Main Theme:

Edited by:

Guy Daculsi and Pierre Layrolle

Pages:

1021-1024

DOI:

10.4028/www.scientific.net/KEM.361-363.1021

Citation:

T. Nasu et al., "EP4 Agonist Accelerates Osteoinduction and Degradation of β-Tricalcium Phosphate in Canine Model", Key Engineering Materials, Vols. 361-363, pp. 1021-1024, 2008

Online since:

November 2007

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Price:

$35.00

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