EP4 Agonist Accelerates Osteoinduction and Degradation of β-Tricalcium Phosphate in Canine Model
Several kinds of biomaterials are known to possess osteoinductive ability without bone inductive substances in ectopic implantation. β-TCP is one such material that has been reported to exhibit this ability in a canine model. In addition, prostaglandin E2 has been proved to accelerate osteogenesis in a rodent model, and one of its receptors EP4 has been considered to play a particularly important role. We examined that the EP4 agonist accelerates β-TCP-induced osteoinduction in a canine model. The results suggested that the EP4 agonist accelerated not only osteoinduction but also osteoclastogenesis prior to bone formation.
Guy Daculsi and Pierre Layrolle
T. Nasu et al., "EP4 Agonist Accelerates Osteoinduction and Degradation of β-Tricalcium Phosphate in Canine Model", Key Engineering Materials, Vols. 361-363, pp. 1021-1024, 2008