Effect of Acid Treated Hydroxyapatite on Osteoblast Maturation

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Surfaces of sintered hydroxyapatite (HAp) were treated with four kinds of acids, hydrochloric acid (HCl), nitric acid (HNO3), sulfuric acid (H2SO4) and hydrogen peroxide (H2O2). On these acid-treated HAp surfaces, osteoblast-like MC3T3-E1 cells were cultured for 20 days. The matrix mineralization was observed in HCl-treated HAp and HNO3-treated HAp, but not in non-treated HAp, H2SO4-treated HAp and H2O2-treated HAp. Gene expressions of Bglap2 encoding osteocalcin and Akp2 encoding alkaline phosphatase were higher in HCl-treated HAp and HNO3-treated HAp than those in the others. These results indicate that not only hydrochloric acid but also nitric acid improves performance of HAp to mature osteoblast.

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Periodical:

Key Engineering Materials (Volumes 361-363)

Main Theme:

Edited by:

Guy Daculsi and Pierre Layrolle

Pages:

1029-1032

Citation:

T. Takemura et al., "Effect of Acid Treated Hydroxyapatite on Osteoblast Maturation", Key Engineering Materials, Vols. 361-363, pp. 1029-1032, 2008

Online since:

November 2007

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$38.00

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