Comparison of Hydroxyapatite with Carbonate Apatite in Osteoclastic Cell Resorptive Activity
Various bioactive calcium phosphates such as hydroxyapatite (HA) and carbonate apatite (CA) bone substitutes have been studied because of the biocompatibility and osteoconductivity when implanted into bone defects. In this study, the interaction between bioceramics and osteoclast-like cell using the cell-line such a RAW264 was examined for the investigation of the important factors of the osteoclastic responses. From the results, the possibility of effectiveness by surface geometry and chemical property means solubility was suggested. Moreover, it was considerable that the CA induced much stronger responses to osteoclast-like cells than the HA.
Guy Daculsi and Pierre Layrolle
N. Ohashi et al., "Comparison of Hydroxyapatite with Carbonate Apatite in Osteoclastic Cell Resorptive Activity", Key Engineering Materials, Vols. 361-363, pp. 1039-1042, 2008