Proliferation of Osteoblast-Like Cells on Zirconia/Alumina Nanocomposite
The aim of this study was to evaluate the biocompatibility with the proliferation of osteoblast-like cell (MC3T3-E1) on zirconia/alumina nanocomposite (NANOZR) in comparison to yttria stabilized zirconia (3Y-TZP) and titanium (Ti). Cellular proliferations after 1-, 3-, 6-, and 9-day incubation were calculated from the measurement of the MTT activities of the proliferated cell and were analyzed by two-way ANOVA. Time-dependent proliferation of MC3T3-E1 in all the sample was observed in all three materials with culture days. However, these were no significant differences in the proliferation between three kinds of material, indicating all the materials have a similar-good biocompatibility.
Guy Daculsi and Pierre Layrolle
D. Yamashita et al., "Proliferation of Osteoblast-Like Cells on Zirconia/Alumina Nanocomposite", Key Engineering Materials, Vols. 361-363, pp. 1099-1102, 2008