Calcium Phosphate Powder for Cancer Vaccination
Cancer cells synthesize abnormal proteins and peptides which are associated to heat shock proteins being overproduced by these cells due to the stress induced by the particular biology of cancer tissue. We have purified on hydroxylapatite powder heat shock proteins using the HAparticles as purification bed, vectors for the proteins and vaccination adjuvant. The powder make possible that the purified HSPs and their associated peptides are transfected to the antigen presenting cells and presented to the T cells for the destruction of the cancer cells bearing the antigens.
Guy Daculsi and Pierre Layrolle
P. Frayssinet et al., "Calcium Phosphate Powder for Cancer Vaccination", Key Engineering Materials, Vols. 361-363, pp. 1207-1210, 2008