Biodegradable Chitosan-Silicate Porous Hybrids for Drug Delivery

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Porous chitosan-silicate hybrids were prepared by freeze-drying the precursor sol solutions synthesized from chitosan and 3-glycidoxypropyltrimethoxysilane (GPTMS). Degradability of and the release of cytochrome C in to phosphate buffer saline solution (PBS) were examined as a function of the GPTMS content. The hybrids were less degradable with larger GPTMS contents, and the cytochrome C release profile was so controllable as to give either burst release or slow one due to the GPTMS content. Thus, the present porous chitosan-silicate hybrids were considered applicable to drug delivery systems.

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Periodical:

Key Engineering Materials (Volumes 361-363)

Main Theme:

Edited by:

Guy Daculsi and Pierre Layrolle

Pages:

1219-1222

Citation:

Y. Shirosaki et al., "Biodegradable Chitosan-Silicate Porous Hybrids for Drug Delivery", Key Engineering Materials, Vols. 361-363, pp. 1219-1222, 2008

Online since:

November 2007

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$38.00

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[80] [60] [40] [20] [0] Cumulative release (%) 302520151050 Soaking period (day) Ch ChG001 ChG01 ChG05 120 100.

[80] [60] [40] [20] [0] Cumulative release (%).

[25] [20] [15] 1050 Soaking period (day) 1000µg 100µg 50µg Fig. 4 Percent cumulative cytochrome C released from the hybrids. *cytochrome C: 50µg/sample Fig. 5 Percent cumulative cytochrome C released from ChG05.

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