Biodegradable Chitosan-Silicate Porous Hybrids for Drug Delivery


Article Preview

Porous chitosan-silicate hybrids were prepared by freeze-drying the precursor sol solutions synthesized from chitosan and 3-glycidoxypropyltrimethoxysilane (GPTMS). Degradability of and the release of cytochrome C in to phosphate buffer saline solution (PBS) were examined as a function of the GPTMS content. The hybrids were less degradable with larger GPTMS contents, and the cytochrome C release profile was so controllable as to give either burst release or slow one due to the GPTMS content. Thus, the present porous chitosan-silicate hybrids were considered applicable to drug delivery systems.



Key Engineering Materials (Volumes 361-363)

Main Theme:

Edited by:

Guy Daculsi and Pierre Layrolle




Y. Shirosaki et al., "Biodegradable Chitosan-Silicate Porous Hybrids for Drug Delivery", Key Engineering Materials, Vols. 361-363, pp. 1219-1222, 2008

Online since:

November 2007




[1] T. Tateishi, G. Chen, and T. Ushida: J Artif Organs, Vol. 5 (2002), p.77.

[2] Biomaterials science; an introduction to materials in medicine, edited by B.D. Ratner, A.S. Hoffman, F.J. Schoen, and J.E. Lemons, Elsevier, Academic Press, (2004).

[3] V.R. Sinha, A.K. Singla, S. Wadhawan, R. Kaushik, R. Kumria, K. Bansal, and S. Dhawan: Inter J Pharmace, Vol. 274 (2004), p.1.

[4] Y. Shirosaki, K. Tsuru, S. Hayakawa, A. Osaka, M.A. Lopes, J.D. Santos, and M.H. Fernandes: Biomaterials, Vol. 26 (2005), p.485.


[5] K. Tsuru, Y. Shirosaki, S. Hayakawa, A. Osaka, M.A. Lopes, J.D. Santos, and M.H. Fernandes: Key Engineering Mateirals, Vol. 284-286 (2005), p.823.


[6] S. Ning, N. Yu, D.M. Brown, S. Kanekal, and S.J. Knox: Radiother Oncol, Vol. 50 (1999), p.215.

[7] R.S. Davis, A.R. Brough, and A. Atkinson: J Non-Cryst Solid, Vol. 315 (2003), p.197.

[8] M.A. Bayomi, S.A. al-Suwayeh, A.M. el-Helw, and A.F. Mesnad: Pharm Acta Helv, Vol. 73 (1998), p.187.


[9] J, Akbuga, and G. Durmaz: Int J Pharm, Vol. 111 (1994), pp.217-100.

[80] [60] [40] [20] [0] Cumulative release (%) 302520151050 Soaking period (day) Ch ChG001 ChG01 ChG05 120 100.

[80] [60] [40] [20] [0] Cumulative release (%).

[25] [20] [15] 1050 Soaking period (day) 1000µg 100µg 50µg Fig. 4 Percent cumulative cytochrome C released from the hybrids. *cytochrome C: 50µg/sample Fig. 5 Percent cumulative cytochrome C released from ChG05.