Biodegradable Chitosan-Silicate Porous Hybrids for Drug Delivery
Porous chitosan-silicate hybrids were prepared by freeze-drying the precursor sol solutions synthesized from chitosan and 3-glycidoxypropyltrimethoxysilane (GPTMS). Degradability of and the release of cytochrome C in to phosphate buffer saline solution (PBS) were examined as a function of the GPTMS content. The hybrids were less degradable with larger GPTMS contents, and the cytochrome C release profile was so controllable as to give either burst release or slow one due to the GPTMS content. Thus, the present porous chitosan-silicate hybrids were considered applicable to drug delivery systems.
Guy Daculsi and Pierre Layrolle
Y. Shirosaki et al., "Biodegradable Chitosan-Silicate Porous Hybrids for Drug Delivery", Key Engineering Materials, Vols. 361-363, pp. 1219-1222, 2008