Controlled Drug Release Using Nanoporous Alumina Capsules
Nano-materials and technology increasingly come under emphasis on application in biomedical treatment and pharmaceutical field. Drug particle with nano-size has better bioactivity and absorptivity, which advance the efficiency of utilization. The nanoporous alumina membranes fabricated by anodization are provided with orderd nanoporous structure, highly uniform pore size, straight and parallel pore channels, moreover, this material possesses favorable biocompatibility. Recently, application of nanoporous alumina membranes in medical science has becoming public concerned in present biomedical material field. Our experiment aimed at fabricating nanoporous alumina membranes with definite mechanical strength to cylindrical biofiltration capsules, which can be used to encapsulate nanodrug to control drug delivery. The release characteristic was examined by monitoring the diffusion of fluorescein isothocyanate (FITC) with molecular weight of 389.4Da as a function of time after encapsulation within the alumina tubes.
Guy Daculsi and Pierre Layrolle
L. Li et al., "Controlled Drug Release Using Nanoporous Alumina Capsules", Key Engineering Materials, Vols. 361-363, pp. 1223-1226, 2008