Impact of Calcium Phosphate Particle Morphology on Osteoconduction: an In Vivo Study


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Apatite/β−TCP particles exhibiting non-conventional urchin-like morphology were prepared by hydrothermal synthesis. Their implantation in the rat calvarium was followed during 60 days. A total absence of osteoconduction was observed despite a favorable chemical composition, stressing the fundamental role of particle morphology on bone regeneration. Results are discussed in relation with other literature data. Possible explanations include the disfavored accumulation of biological mediators due to the acicular shape of the particles and/or a limited accessibility for cells.



Key Engineering Materials (Volumes 361-363)

Main Theme:

Edited by:

Guy Daculsi and Pierre Layrolle






C. Drouet et al., "Impact of Calcium Phosphate Particle Morphology on Osteoconduction: an In Vivo Study", Key Engineering Materials, Vols. 361-363, pp. 1237-1240, 2008

Online since:

November 2007




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