Improvement of Radio Opacity of Injectable Bone Substitute MBCP GelTM for Minimal Invasive Surgery MIS

Abstract:

Article Preview

Dedicated to Minimal Invasive Surgery MIS particularly in spine for vertebroplasty, the surgeons and radiologists ask for improvement of radio opacity, to be sure of the injection site, and to prevent injection in blood vessels. MBCP Gel® is an Injectible biomaterial non self hardening, the biomaterials consists of BCP granules associated with a hydrosoluble polymer. These materials have been shown to be perfectly biocompatible and potentially resorbable and, thanks to their initial plasticity, they assume the shape of the bone defects very easily, eliminating the need to shape the material to adjust to the implantation site. MBCP gels do not have mechanical properties like the hydraulic bone cements. However bone cells are able to invade the spaces created by the disappearance of the polymer carrier. Bone ingrowth takes place all around the granules at the expense of the resorption of the BCP granules. In time, the mechanical property is increased due to the presence of the newly formed bone. This study demonstrates an improvement of MBCP gel by freeze drying and reconstitution using iodine solution or sterile water in a classical model of rabbit bone defects.

Info:

Periodical:

Key Engineering Materials (Volumes 361-363)

Main Theme:

Edited by:

Guy Daculsi and Pierre Layrolle

Pages:

1277-1280

Citation:

G. Daculsi et al., "Improvement of Radio Opacity of Injectable Bone Substitute MBCP GelTM for Minimal Invasive Surgery MIS", Key Engineering Materials, Vols. 361-363, pp. 1277-1280, 2008

Online since:

November 2007

Export:

Price:

$41.00

[1] Daculsi G., Weiss P., Bouler J.M., Gauthier O., Aguado E. (1999) Bone, 25: 59-61.

[2] Gauthier O, Bouler Jm, Aguado E, Legeros R, Pilet P, Daculsi G. J Of Mater Sc : Mat In Med, 1999, 10: 199-204.

DOI: https://doi.org/10.1023/a:1008949910440

[3] Gauthier O, Bouler Jm, Weiss P, Bosco J, Daculsi G, Aguado E. J Biomed Mater Res, 1999, 47(1) : 28-35.

[4] Daculsi G., Biphasic calcium phosphate Granules concept for Injectable and Mouldable Bone Substitute: (2006). Advances in Science and Technology Volume 49, Trans Tech Publications, Switzerland, pp.9-13.

DOI: https://doi.org/10.4028/www.scientific.net/ast.49.9

[5] Saffarzadeh A, Gauthier O, Humbert T, Weiss P, Bouler JM, Daculsi G. Maxillary sinus bone grafting with an Injectable Bone Substitute: a sheep study. Key Engineering Materials. 2004; 254-256: 193-6.

DOI: https://doi.org/10.4028/www.scientific.net/kem.254-256.193

[6] Weiss P, Layrolle P, Clergeau LP, Enckel B, Pilet P, Amouriq Y, Daculsi G, Giumelli B. (2007) Biomaterials. Apr 10; 28: 3295-305.

DOI: https://doi.org/10.1016/j.biomaterials.2007.04.006

[7] Fabre T , Chauveaux D., Moinard M., Mais C., Durand M., Pollart C., Daculsi G. (2007) Key Engineering Materials vols 333-334, in press, Trans Tech Publication Switzerland.

[8] Daculsi G., Mousselard H., Goyenvalle E., Pilet P., Delplace S., Aguado E.,. Key engineering Materials 2005, vols 284-286: 803-806.

DOI: https://doi.org/10.4028/www.scientific.net/kem.284-286.803

[9] Mainard D. Monographie du GEST (2005), www. maitrise-orthop. com/gesto.

[10] Niwa S, LeGeros RZ (2002). Tissue Engineering and Biodegradable Equivalents. Scientific and Clinical Applications. Marcel Dekker, New York, pp.385-400.

[11] Le Guehennec L, Layrolle P, Daculsi G. Eur Cell Mater. 2004 Sep 13; 8: 1-11.