Human Dentin Transplantation for Bone Engineering


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The aims of this study are to confirm the capacity of hard tissue induction by human demineralized dentin matrics (DDM) and calcified dentin matrics (CDM) in subcutaneous tissues of nude mice, and to report a human pioneering trial following the autotransplantation of DDM for bone augmentation in a case of the atrophied upper jaw. Human DDM and CDM particles were prepared from adult, extracted vital teeth, and were implanted into the subcutaneous tissues of 4-week-old nude mice. DDM induced bone and cartilage independently at 4 weeks after implantation, while CDM did not induce a hard tissue formation. Autogenous DDM prepared from the non-functional second molar of a 58-year-old female were grafted on the atrophied jaw and received to the host. Human dentin can be recycled as autogenous biomaterials for local bone engineering.



Key Engineering Materials (Volumes 361-363)

Main Theme:

Edited by:

Guy Daculsi and Pierre Layrolle




M. Murata et al., "Human Dentin Transplantation for Bone Engineering", Key Engineering Materials, Vols. 361-363, pp. 1327-1330, 2008

Online since:

November 2007




[1] J.D. Yeomans, and M.R. Urist: Arch Oral Biol, 12: 999-1008, (1967).

[2] G. Bang, and M.R. Urist: Arch. Surg., 94: 781-789, (1967).

[3] C. Huggins, S. Wiseman, and A.H. Reddi: J. Exp. Med., 132: 1250-1258, (1970).

[4] W.T. Butler, A. Mikulski, M.R. Urist, G. Bridges, and S. Uyeno: J. Dent. Res, 56: 228-232, (1977).

[5] K. Bessho, N. Tanaka, J. Matsumoto, T. Tagawa, and M. Murata: J. Dent. Res, 70: 171-175, (1991).

[6] A.H. Reddi, and C.B. Huggins: Proc. Soc. Exp. Biol. Med. Jull., 43: 634-637, (1973).

[7] M.R. Urist: Science, 150: 893-899, (1965).

[8] J.M. Wozney, V. Rosen, A.J. Celeste, L.M. Mitsock, J.M. Whitters, R.M. Kriz, R.M. Hewick and E.A. Wang: Science, 242: 1528-1534, (1988).


[9] A.H. Reddi: Adv. Med. Phys., 15: 1-17, (1974).

[10] M.R. Urist, H. Iwata, P.W.L. Ceccotti, R.L. Dorfman, S.D. Boyd, R.M. McDowell, and C. Chien: Proc. Nat. Acad. Sci., 70: 3511-3515, (1973).