Antibacterial Effects of Sol-Gel Derived Zinc-Containing Hydroxyapatite


Article Preview

In order to modify the biological properties of pure hydroxyapatite (HAp), two kinds of zinc-containing HAp, which had zinc content of 5.10wt% and 2.54wt%, respectively, were synthesized via sol-gel technique. The obtained coatings were characterized by X-ray diffraction (XRD) and scanning electron microscope (SEM). Then the antibacterial effects were evaluated through bacteriostatic test on Streptococcus mutans (S.mutans) in vitro and zinc ions releasing ability was investigated through detecting the zinc ions concentration by inductively coupled plasma-atomic emission spectroscopy (ICP-AES). The obtained coatings were observed to possess typical apatite peaks in XRD patterns and high homogeneous and porous surfaces in SEM morphology. The coating layer demonstrated good releasing ability in Brain Heart Infusion (BHI) liquid and obviously inhibitory effects to the growth and proliferation of S. mutans. Based on the results obtained above, it is concluded that the sol-gel derived zinc-containing hydroxyapatite could be applied as an antibacterial effective biomaterial.



Key Engineering Materials (Volumes 361-363)

Main Theme:

Edited by:

Guy Daculsi and Pierre Layrolle




X. C. Shi et al., "Antibacterial Effects of Sol-Gel Derived Zinc-Containing Hydroxyapatite", Key Engineering Materials, Vols. 361-363, pp. 139-142, 2008

Online since:

November 2007




[1] R.L. William, in: Hydroxyapatite Coatings, edited by L.L. Hench and J. Wilson, page 223-38 of An Introduction to Bioceramics, World Scientific (1993).

[2] J.L. Ong and D.C.N. Chan: Crit. Rev. Biomed. Eng. Vol. 28 (2000), p. 667A.

[3] D.M. Liu, Q. Yang and T. Troczynski, et al: Biomater. Vol. 23 (2002), p.1679.

[4] R.G.T. Geesink: Clin. Orthop. Vol. 261 (1990), p.39.

[5] T.W. Bauer, R.G.T. Geesink and R. Zimmerman: J. Bone Jt. Surg. Vol. 73A (1991), p.1439.

[6] M. Quirynen, M. De Soete and D. van Steenberghe: Clin. Oral Impl. Res. Vol. 13 (2002), p.1.

[7] S. Hidaka, Y. Okamoto and K. Abe: J. Biomed. Mater. Res. Vol. (1994), p.175.

[8] A. Bigi, E. Foresti, and M. Gandolfi, et al: .J. Inorg. Biochem. Vol. 58 (1995), p.49.

[9] Y. Okamoto and S. Hidaka: J. Biomed. Mater. Res. Vol. 28 (1994), p.1403.

[10] T.N. Kim, Q.L. Feng and J.O. Kim, et, al: J. Mater. Sci. Mater. Med. Vol. 9 (1998), p.129.

[11] G.L. Alexia, L. Patrice and J. Edouard, et al: Biomater. Vol. 27 (2006), p.3195.

[12] R. J. Chung, M. F. Hsieh and K. C. Huang: J. Biomed. Mater. Res. Vol. 76 (2006).