Preparation of Porous Synthetic Nanostructured HA Scaffold


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The low temperature macro and micro porous hydroxyapatite scaffold was synthesized. The synthetic nanostructured HA powder was prepared by the reaction of Ca(OH)2 and H3PO4. The ultrasound apparatus was used for the separation of the particles during the precipitation process. Hydrogen peroxide (H2O2) was used as a foaming agent. The samples were dried for 3 hours at 120°C. HA (hydroxyapatite) granules exhibited interconnected macro and micro porosity with the micro pore size in the order of 0.01 'm. The specific surface area of the precipitate reached the average value 64.8 ± 11.9 [m2.g-1]. The compressive strength of the low temperature porous HA scaffold granule was very similar to deproteinized bovine bone and other calcium phosphate ceramic materials used in bone regeneration and prepared by high temperature processes. The porosity of the scaffolds 50-75% was determined by mercury porosimetry. In-vitro cytotoxicity test proved the granules to be non toxic.



Key Engineering Materials (Volumes 361-363)

Main Theme:

Edited by:

Guy Daculsi and Pierre Layrolle




M. Strnadová et al., "Preparation of Porous Synthetic Nanostructured HA Scaffold", Key Engineering Materials, Vols. 361-363, pp. 211-214, 2008

Online since:

November 2007




[1] R. Z. LeGeros (1991), Calcium Phosphates in Oral Biology and Medicine, Chap. 6, H. M. Myers, ed., Karger, Basel pp.110-118.

[2] S. Zhang and K. E. Gonsalves (1997) J. Mater. Sci.: Mater. Med. 8: 25-28.

[3] M. Navarro,S. del Valle, S. Martinez, S. Zeppetelli, et al. (2004) Biomaterials 25 pp.4233-4241.

[4] D. Tadic, M. Epple (2004), Biomaterials 25 : 987-994 Fig. 3. SEM photograph HA120 scaffold Fig. 4. SEM photograph of HA 120 peroxide scaffold.