Bioresorbable Phosphate Scaffolds for Bone Regeneration


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In this work, a new bioresorbable phosphate glass (I-CEL2) was prepared in order to use it for the production of 3D-bioresorbable scaffold for bone regeneration. I-CEL2 was characterized to assess its thermal characteristics as well as its bioresorption rate in different medium such as distilled water, Tris-HCl and Simulated Body Fluid (SBF). 3D-macroporous scaffolds were prepared by mixing and pressing I-CEL2 powders and an organic phase and by treating the compact of powders at 550°C for 3 hours. The obtained scaffolds showed a very high porosity and a high resorption rate and are thus suitable candidates for a scaffold to be used as a temporary guide for bone regeneration. The initial response of human marrow stromal cells (hMSCs) has been tested on I-CEL2 surface to describe its biological potential.



Key Engineering Materials (Volumes 361-363)

Main Theme:

Edited by:

Guy Daculsi and Pierre Layrolle




C. Vitale-Brovarone et al., "Bioresorbable Phosphate Scaffolds for Bone Regeneration", Key Engineering Materials, Vols. 361-363, pp. 241-244, 2008

Online since:

November 2007




[1] H. Gao, T. Tan and D. Wang: J. Controll. Rel. 96 (2004), p.29.

[2] K. Franks, I. Abrahams and J. Knowles: J. Mat. Sci. 11 (2000), p.609.

[3] I.D. Xynos, A.J. Edgar, L.D.K. Buttery, L.L. Hench and J.M. Polak: J. Biomed. Mater. Res. 155 (2000), p.35.

[4] C. Vitale-Brovarone, E. Verné and P. Appendino: J. Mater. Sci.: Mater. Med. 17 (2006), p.1069.