There is a current need for the localized delivery of antibiotics in order to treat implant based infections. In this study, the efficacy of hydroxyapatite (HA) gels, HA cements, and silica gels in the delivery of vancomycin have been investigated and compared. Vancomycin release was monitored at set time points using a UV/VIS spectrophotometer (288 nm). The activity of the vancomycin released from the cements and gels was assessed using an agar diffusion test with Staphylococcus aureus. Vancomycin was released rapidly from both HA matrices, and the silica gel in the first day of the experiment, but the release rate was slowed considerably after 3 days for the HA gels. Following ten days of aging, 70% of the vancomycin remained in the HA gel matrix and the quantity released from the gel was shown to retain its effectiveness against Staphylococcus aureus.