Effect of Storage Conditions Prior to Mixing of β-TCP Based Bone Cement on the Reaction Products and the Setting


Article Preview

β-tricalcium phosphate (β-TCP) based cement features unique biodegradability and mild temperature rise as a material for bone reconstruction. However, the bone cement often raises a shelf life issue and therefore study was made focusing on the temperature and humidity during storage. With the increase of storing days, the density and compressive strength of hardened cement were found to drastically decrease for the cement powder stored in a mixed state. In addition, the setting property was finally lost at the same time. Such a degradation was more evident at higher temperature and was the result of the formation of dicalcium phosphate anhydrous (DCP) instead of dicalcium phosphate dehydrate (DCPD) during the storage. On the contrary, for the cement stored in an unmixed state, very slight changes were detected in density, compressive strength and setting time with the increase of storing days even if the powders were kept in a humid environment. In the unmixed ones, DCP was not precipitated regardless of the storing temperature. Discussion was made on the condition for precipitating either DCPD or DCP in terms of the amount of water supplied during setting. Practically the work suggested that the β-TCP based cement needs to be conserved at lower temperature and in dry environment as possible to effectively increase the shelf life.



Key Engineering Materials (Volumes 361-363)

Main Theme:

Edited by:

Guy Daculsi and Pierre Layrolle




S. A. Lee et al., "Effect of Storage Conditions Prior to Mixing of β-TCP Based Bone Cement on the Reaction Products and the Setting", Key Engineering Materials, Vols. 361-363, pp. 351-354, 2008

Online since:

November 2007




[1] K-S Oh, S-R Kim and Philippe Boch, (2004) Key Engineering Materials 254-256: 237-240.

[2] K. -S Oh, H-W Choi, S-R Kim, (2005) Current Applied Physics 5: 489-492.

[3] Uwe Gbureck, Sofia Dembski, Roger Thull, and J.E. Barralet. (2005) Biomaterials 26 3691-3697.

DOI: https://doi.org/10.1016/j.biomaterials.2004.09.036

[4] E. Fernandez, F.J. Gil, M.P. Ginebra, F.C.M. Driessens, J.A. Planell, S.M. Best (1999) J. Mater. Sci.: Mater. Med. 10 : 169-176 Acknowledgements This work was supported by a grant from 2005 Research Fund of Andong National University.