Timed-Release Calcium Sulfate Ceramic Nanocomposites as Bone Graft Substitutes


Article Preview

Pure calcium sulfate (CS) is an excellent bone graft material because it is biocompatible, completely biodegradable, osteoconductive, safe, nontoxic and angiogenic. It also has barrier properties. However, its rapid degradation limits its use as a bone graft material. A nanocomposite of CS and poly (l lactic acid) (PLLA) in a ratio of 96:4 was developed to overcome this problem. This composite underwent slower degradation. It took 16 weeks for complete degradation whereas pure CS takes only 4 weeks. When implanted in bone defects in rabbits, it underwent complete degradation and stimulated vigorous bone formation.



Key Engineering Materials (Volumes 361-363)

Main Theme:

Edited by:

Guy Daculsi and Pierre Layrolle




S. Mamidwar et al., "Timed-Release Calcium Sulfate Ceramic Nanocomposites as Bone Graft Substitutes", Key Engineering Materials, Vols. 361-363, pp. 391-394, 2008

Online since:

November 2007




[1] Dreesmann H. Ueber Knockenplombierung. Beitr Lin Chir 1892; 9: 804.

[2] Peltier LF. The use of plaster of Paris to fill large defects in bone: a preliminary report. 1959. Clin Orthop Relat Res 2001(382): 3-5.

[3] Ricci JL, Alexander H, Nadkarni P, Hawkins M, Turner J, Rosenblum S, Brezenoff L, DeLeonardis D, Pecora G. Biological Mechanisms of Calcium Sulfate Replacement by Bone. Bone Engineering, Ed. By. Davies J., em2 Inc. Toronta, Canada 2000: 332-344.