Elastic Ceramic-Polymer Scaffold with Interconnected Pore Structure: Preparation and In Vitro Reactivity
A series of ceramic-polymer scaffolds were studied for bone tissue engineering applications. These applications require bone reactivity as well as suitable scaffold properties and structure. Bioactive glass (BAG) and sol-gel derived silicas were chosen for ceramic components of the scaffolds, and crosslinked poly(ε-caprolactone/D,L-lactide) copolymers with monomer ratios 90/10 and 70/30 were used as polymer matrices. Scaffolds were prepared by photo-curing crosslinkable oligomers in the presence of the ceramic component and porosity producing salt. Scaffolds with 60-80 vol-% continuous phase macroporosity were obtained by using calcium chloride hexahydrate (CaCl2⋅6H2O), and were further tested in simulated body fluid (SBF). The ceramics remained highly reactive during scaffold preparation resulting in in vitro calcium phosphate formation.
Guy Daculsi and Pierre Layrolle
M. Malin et al., "Elastic Ceramic-Polymer Scaffold with Interconnected Pore Structure: Preparation and In Vitro Reactivity", Key Engineering Materials, Vols. 361-363, pp. 395-398, 2008