Elastic Ceramic-Polymer Scaffold with Interconnected Pore Structure: Preparation and In Vitro Reactivity

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A series of ceramic-polymer scaffolds were studied for bone tissue engineering applications. These applications require bone reactivity as well as suitable scaffold properties and structure. Bioactive glass (BAG) and sol-gel derived silicas were chosen for ceramic components of the scaffolds, and crosslinked poly(ε-caprolactone/D,L-lactide) copolymers with monomer ratios 90/10 and 70/30 were used as polymer matrices. Scaffolds were prepared by photo-curing crosslinkable oligomers in the presence of the ceramic component and porosity producing salt. Scaffolds with 60-80 vol-% continuous phase macroporosity were obtained by using calcium chloride hexahydrate (CaCl2⋅6H2O), and were further tested in simulated body fluid (SBF). The ceramics remained highly reactive during scaffold preparation resulting in in vitro calcium phosphate formation.

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Periodical:

Key Engineering Materials (Volumes 361-363)

Main Theme:

Edited by:

Guy Daculsi and Pierre Layrolle

Pages:

395-398

Citation:

M. Malin et al., "Elastic Ceramic-Polymer Scaffold with Interconnected Pore Structure: Preparation and In Vitro Reactivity", Key Engineering Materials, Vols. 361-363, pp. 395-398, 2008

Online since:

November 2007

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$38.00

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