Formation of an FGF-2-Apatite Composite Layer on Ethylene-Vinyl Alcohol Copolymer


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A composite layer of fibroblast growth factor-2 (FGF-2) and low-crystalline apatite was formed on an ethylene-vinyl alcohol copolymer specimen using two types of aqueous calcium phosphate solutions supplemented with 10 !g·mL-1 FGF-2; one is a CP solution that is prepared by dissolving chemical reagents into ultrapure water and the other is an RKB solution that can be prepared by mixing clinically approved infusion fluids. In both solutions, a sufficient amount of FGF-2 for new skin tissue formation (1 !g·cm-2) was immobilized on the specimen surface.



Key Engineering Materials (Volumes 361-363)

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Edited by:

Guy Daculsi and Pierre Layrolle




K. Sasaki et al., "Formation of an FGF-2-Apatite Composite Layer on Ethylene-Vinyl Alcohol Copolymer", Key Engineering Materials, Vols. 361-363, pp. 455-458, 2008

Online since:

November 2007




[1] A. Oyane, K. Hyodo, M. Uchida, Y. Sogo and A. Ito: Key Eng. Mater. Vol. 309-311 (2006) p.1181.

[2] A. Oyane, M. Uchida and A. Ito: J. Biomed. Mater. Res. Vol. 72A (2005) p.168.

[3] Y. Sogo, A. Ito, M. Onoguchi et al.: Biomed. Mater. in press.

[4] Y. Sogo, A. Ito, H. Mutsuzaki, A. Oyane, M. Onoguchi, N. Ichinose, M. Sakane and N. Ochiai: Key Eng. Mater. Vol. 330-332 (2007) p.691.


[5] A. Oyane, M. Uchida, Y. Ishihara and A. Ito: Key Eng. Mater. Vol. 284-286 (2005) p.227.

[6] J.S. Wang and P. Aspenberg: Clin. Orthop. Res. Vol. 333 (1996) p.252.