Rigid Hydroxyapatite-Alginate Beads for Sustained Release of Paclitaxel
Rigid hydroxyapatite (HAp)-alginate beads were prepared as drug delivery carriers for an anti-cancer drug, paclitaxel (Taxol). Paclitaxel was loaded into the HAp microparticle in process of a spray-drying technique. The HAp-alginate beads including paclitaxel were obtained by a droplet method into barium solution as ionic cross-linkage and dehydration. Cross-sectional analyses indicated the homogeneity of HAp microparticles and barium ions inside the bead. The ratio of alginate to HAp in the beads dominated both mechanical and swelling properties. Drug-release experiment demonstrated the sustained release of paclitaxel from the beads cross-linked with barium ion for 7 days.
Guy Daculsi and Pierre Layrolle
T. Ikoma et al., "Rigid Hydroxyapatite-Alginate Beads for Sustained Release of Paclitaxel", Key Engineering Materials, Vols. 361-363, pp. 535-538, 2008