Ternary Bio-Nanostructured Systems Prepared under High Pressure Conditions


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Many researchers have assumed that a combination of hydroxyl apatite (HAP) and collagen (COL) may be the best solution for bone replacement and have prepared their composites by several techniques [1]. However, such HAP/COL composite had no nanostructure similar to bone, and consequently indicated no bone-like mechanical properties. These results demonstrate that the chemical composition similar to bone only is insufficient for bone metabolism and mechanical properties. Mechanical and biological performance of this type of materials could be improved by adding TiO2 within the initial mixture of nanostructured composites [2]. Ternary nanostructured systems consisting of hydroxyl apatite, TiO2 aerogel and collagen were prepared for the first time by hydrothermal procedure in high pressure conditions. Among many advantages, the synthesis method proposed in this paper could lead to formation of chemically bonded compounds as a consequence of high pressure conditions. The resulted material could find applications in bone tissue regenerative medicine, either in powder form for bone defects treatment, or in matrix form as osteoconductive coating for metal implants. Further studies are necessary to evaluate the osteoconductive properties.



Key Engineering Materials (Volumes 361-363)

Main Theme:

Edited by:

Guy Daculsi and Pierre Layrolle




R. M. Piticescu et al., "Ternary Bio-Nanostructured Systems Prepared under High Pressure Conditions", Key Engineering Materials, Vols. 361-363, pp. 539-542, 2008

Online since:

November 2007




[1] M. Kikuchi, T. Ikoma, S. Itoh, et al. (2004) Composite Science and Technology 64: 819-25.

[2] J. Harle, H-W. Kim, N. Mordan, et al. (2006) Acta Biomateriala 2: 547-56.

[3] Park, B. /S., Heo, S.J., Kim, C.S., Oh, J.E., Kim, J.M., Lee, G., Parkm W.H., Chung, C.P., Min, B.M., Effects of adhesion molecules on the behavior of osteoblast-like cells and normal human fibroblasts on different titanium surfaces. J Biomed Mater Res A. 74, 640-651, (2005).

DOI: https://doi.org/10.1002/jbm.a.30326

[4] OpriŃa, E.I., Moldovan, L., Crãciunescu, O., Buzgariu, W., Tardei, C., Zãrnescu, O., A bioactive collagen-β tricalcium phosphate scaffold for tissue engineering, Central European Journal of Biology, 1, 61-72, (2006).

DOI: https://doi.org/10.2478/s11535-006-0005-7