Carbonated-Apatite/Gelatine Porous Scaffolds for Bone Replacement
A novel foaming method of design and synthesis of porous Carbonate-apatite/gelatine composite scaffolds is proposed for biomedical applications. Two different suspensions, one constituted by a biomimetic inorganic phase (B-CHA) and the second by a protein (gelatine), are mixed, foamed, lyophilized and, in some cases, cross-linked to stabilize the organic phase. Chemical, morphological and mechanical features of the scaffolds are evaluated. The samples have chemical composition, compressive and flexural strengths and Young modulus values in the range of trabecular bone ones. A high interconnected porosity (about 90%) showing a micro- to macrosize distribution, that is needed for osteoconduction and vascolarization processes in vivo, is also detected.
Guy Daculsi and Pierre Layrolle
E. Landi et al., "Carbonated-Apatite/Gelatine Porous Scaffolds for Bone Replacement", Key Engineering Materials, Vols. 361-363, pp. 547-550, 2008