Carbonated-Apatite/Gelatine Porous Scaffolds for Bone Replacement


Article Preview

A novel foaming method of design and synthesis of porous Carbonate-apatite/gelatine composite scaffolds is proposed for biomedical applications. Two different suspensions, one constituted by a biomimetic inorganic phase (B-CHA) and the second by a protein (gelatine), are mixed, foamed, lyophilized and, in some cases, cross-linked to stabilize the organic phase. Chemical, morphological and mechanical features of the scaffolds are evaluated. The samples have chemical composition, compressive and flexural strengths and Young modulus values in the range of trabecular bone ones. A high interconnected porosity (about 90%) showing a micro- to macrosize distribution, that is needed for osteoconduction and vascolarization processes in vivo, is also detected.



Key Engineering Materials (Volumes 361-363)

Main Theme:

Edited by:

Guy Daculsi and Pierre Layrolle




E. Landi et al., "Carbonated-Apatite/Gelatine Porous Scaffolds for Bone Replacement", Key Engineering Materials, Vols. 361-363, pp. 547-550, 2008

Online since:

November 2007




[1] R.Z. Le Geros in: Calcium Phosphates in oral biology and medicine, edited by H. Myers, volume 15 of Monographs in Oral Science, Chapter 5, Karger AG Publishers (1991).

[2] E. Landi, G. Celotti, G. Logroscino and A. Tampieri: J. Eur. Cer. Soc. 23 (2003) p.2931.

[3] C.H. Yao, J.S. Sun, F.H. Lin, C.J. Liao et al. Mater. Chem. Phys. 45 (1996), p.6.

[4] A. Tampieri, G. Celotti, E. Landi, M. Montevecchi, N. Roveri, A. Bigi, S. Panzavolta and M.C. Sidoti: J. Mat. Sci.: Mat. Med. 14 (2003), p.623.

[5] T.M. Keaveny in: Cancellous bone, Handbook of Biomaterial Properties, edited by J. Black & G. Hastings, Chapman & Hall Publishers, London (1998).

[6] S.A. Goldstein, D.L. Wilson, D.A. Sonstegard and L.S. Mattews: J. Biomech. 16 (1983), p.965.

[7] K.A. Athanasiou, C.F. Zhu and D.R. Lanctot: Tissue Eng. 6 (2000) p.361.