Influence of Cross-Linking Agents on Apatite-forming Ability of Pectin Gels


Article Preview

Natural bone is a kind of organic-inorganic hybrid composed of collagen and apatite crystals with a structure that provides specific mechanical properties such as high fracture toughness and flexibility. Materials exhibiting both high flexibility and bioactivity similar to natural bone are required for novel bone-repairing materials in medical fields. We expect that we can design such materials by mimicking the bone structure. Biomimetic process has been paid much attention where bone-like apatite is deposited on organic polymers in simulated body fluid (SBF). In this study, we investigated influence of cross-linking agents on apatite-forming ability of pectin gels. Pectin is a polysaccharide abundant in carboxyl group. Pectin gels were prepared by cross-linking of pectin aqueous solutions with calcium ions or divinylsulfone (DVS). Apatite-forming ability of the gels was examined in SBF. The citrus-derived pectin showed tendency to form the largest amount of the apatite independent on a kind of cross-linking agents in SBF.



Key Engineering Materials (Volumes 361-363)

Main Theme:

Edited by:

Guy Daculsi and Pierre Layrolle




T. Ichibouji et al., "Influence of Cross-Linking Agents on Apatite-forming Ability of Pectin Gels ", Key Engineering Materials, Vols. 361-363, pp. 559-562, 2008

Online since:

November 2007




[1] T. Kokubo, H. Kushitani, S. Sakka, T. Kitusgi and T. Yamamuro (1990) J. Biomed. Mater. Res., 24, 331, 721-734.

[2] T. Kokubo, H. -M. Kim and M. Kawashita (2003) Biomaterials 24, p.2161.

[3] M. Tanahashi and T. Matsuda (1997) J. Biomed. Mater. Res. 34, p.305.

[4] M. Kawashita, M. Nakao, M. Minoda, H.M. Kim, T. Beppu, T. Miyamoto, T. Kokubo and T. Nakamura (2003) Biomaterials, 24, pp.2477-2484.

DOI: 10.1016/s0142-9612(03)00050-4

[5] B.R. Thakur, R.K. Singh and A.K. Handa (1997) Critical Reviews in Food Science and Nutrition, 37(1), 47-74.

Fetching data from Crossref.
This may take some time to load.