PL DLLA Calcium Phosphate Composite Combined with MBCP Gel® for New Surgical Technologies: Resorbable Osteosynthesis and Bone Substitute


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We have performed and evaluated a composite combining PL DLLA and PCa able to have a better control of the hydrolysis and maintain of the mechanical property on time, until wound healing was achieved. Bioabsorbable osteoconductive composite is devoted to the development of resorbable osteosynthesis for spine and osteoarticular surgeries. Such resorbable osteosynthesis will be associated to new bone substitute having high osteogenic property but without initial mechanical property. The purpose of this study was to evaluate the resorption kinetic of a composite using PL DLLA (Poly [L-Lactide-co-D,L-Lactide] acide) charged with PCa granules and the interaction with injectable bioceramic without self hardening. MBCP gel® is a composite associating a mineral phase of an intimate nanoscale melting of hydroxyapatite and beta tri calcium phosphate and an aqueous phase containing a synthetic polymer derived from cellulose HPMC (hydroxyl propyl methyl cellulose).



Key Engineering Materials (Volumes 361-363)

Main Theme:

Edited by:

Guy Daculsi and Pierre Layrolle




G. Jouan et al., "PL DLLA Calcium Phosphate Composite Combined with MBCP Gel® for New Surgical Technologies: Resorbable Osteosynthesis and Bone Substitute", Key Engineering Materials, Vols. 361-363, pp. 571-574, 2008

Online since:

November 2007




[1] Lajtai G., Schmiedhuber G., Unger F., Aitzetmuller G., Klein M., Noszian I., Orthner E., (2001) Arthroscopy 17: 597-602.


[2] Barber F.A., Boothby M.H., (2007) Arthroscopy 23: 476-81.

[3] Rotunda AM, Narins RS (2007), Dermatol Ther. 2006 May-Jun; 19(3): 151-8.

[4] Magarelli N., Savastano M.A., Palmieri D., ZAppacosta R., Lattanzio G., Salini V., Orso C.A., Guglielmi G., Colosimo C., ( 2007), Int. J. Immunopathol. Pharmacol. 20: 207-11.


[5] Daculsi G., Weiss P., Bouler J.M., Gauthier O., Aguado E. (1999) Bone, 25: 59-61.

[6] Gauthier O, Bouler Jm, Aguado E, Legeros Rz, Pilet P, Daculsi G. J Of Mater Sc : Mat In Med, 1999, 10: 199-204.


[7] Gauthier O, Bouler Jm, Weiss P, Bosco J, Daculsi G, Aguado E. J Biomed Mater Res, 1999, 47(1) : 28-35.

[8] Gauthier O., Bouler J.M., Weiss P., Bosco J., Aguado E., Daculsi G. Bone. 1999 Aug; 25(2 Suppl): 71s-74s.

[9] Niwa S, LeGeros RZ (2002). Tissue Engineering and Biodegradable Equivalents. Scientific and Clinical Applications. Marcel Dekker, New York, pp.385-400.

[10] Cotton N., (2007) www: smith-nephew. com.

[11] Weiss P, Layrolle P, Clergeau LP, Enckel B, Pilet P, Amouriq Y, Daculsi G, Giumelli B. (2007), Biomaterials. 2007 Aug; 28(22): 3295-305.