Surface Functionalization of Biomaterials with Alkaline Phosphatase

Abstract:

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Two different glasses, one biocompatible but with a low bioactivity index (G1) and the other with an higher bioactivity index (G2), the ceramic version of the second glass and a titanium alloy (Ti6Al4V) have been functionalizated by anchoring alkaline phosphatase (ALP) on their surfaces. The enzyme has been chosen because it is involved in mineralization processes of hard tissues and is a model for more complex ones. ALP has been grafted on glasses and glass-ceramics surfaces both with and without samples silanization and on metallic surfaces with and without tresyl chloride activation. Samples have been analyzed at each step of the functionalization process in order to verify it.

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Periodical:

Key Engineering Materials (Volumes 361-363)

Main Theme:

Edited by:

Guy Daculsi and Pierre Layrolle

Pages:

593-596

Citation:

E. Verné et al., "Surface Functionalization of Biomaterials with Alkaline Phosphatase", Key Engineering Materials, Vols. 361-363, pp. 593-596, 2008

Online since:

November 2007

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$38.00

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