DNA-Coatings: Bioactive Properties and Effects on Osteoblast-Like Cells
The aim of this study was to evaluate potential effects of DNA-coatings on calcium phosphate (CaP) nucleation from simulated body fluids (SBF) and subsequently the effects of DNA-coatings and SBF-immersed DNA coatings on the behavior of osteoblast-like cells. DNAcoatings demonstrated to enhance the nucleation and deposition of CaP from SBF compared to titanium controls. The behavior of osteoblast-like cells was affected on SBF-immersed DNAcoatings, showing an increased deposition of the extracellular matrix protein osteocalcin compared to titanium controls. These results indicate bone-bonding capacity of DNA-coatings, which needs to be confirmed using future animal experiments.
Guy Daculsi and Pierre Layrolle
J. J.J.P. van den Beucken et al., "DNA-Coatings: Bioactive Properties and Effects on Osteoblast-Like Cells", Key Engineering Materials, Vols. 361-363, pp. 605-608, 2008