Structure and In Vitro Solubility of Silicon-Substituted Hydroxyapatite
Hydroxyapatite (HAp) and Si-containing hydroxyapatite (SiHAp) particles were synthesized by a wet chemical method. Local structures around Si, P and H in the hydroxyapatites were analyzed by solid-state magic-angle spinning nuclear magnetic resonance spectroscopy. In vitro solubility of those SiHAp particles was evaluated by soaking them in acetic acid/acetate buffer solution (pH=4.0) at 36.5°C. As the Si content increased, the in vitro solubility of the SiHAp particles increased, while their crystallite size changed little.
Guy Daculsi and Pierre Layrolle
T. Kanaya et al., "Structure and In Vitro Solubility of Silicon-Substituted Hydroxyapatite", Key Engineering Materials, Vols. 361-363, pp. 63-66, 2008