Synthesis and Phase Stability of Silicate-Substituted α-Tricalcium Phosphate

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Silicate-substituted calcium phosphates have been shown to result in enhanced biological performance compared to the corresponding, silicate-free, calcium phosphates. We have produced a range of silicate-substituted alpha-TCP compositions using two different synthesis methods and two different substitution mechanisms. Single phase compositions were only observed for a silicate substitution of 1.3 wt% by both solid state synthesis and aqueous precipitation synthesis, although the latter was the result of a design composition with a higher silicate substitution (3 wt%). The silicate substitution resulted in small changes in the unit cell parameters of the alpha-TCP. More importantly, this small level of silicate substitution had a strong effect on the thermal stability of the alpha-TCP phase, with the silicate substitution stabilising the alpha-polymorph to lower temperatures. This has an immediate advantage in that the quenching conditions are not as critical for the production of silicate-substituted alpha-TCP compositions compared to silicate-free alpha- TCP.

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Periodical:

Key Engineering Materials (Volumes 361-363)

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Edited by:

Guy Daculsi and Pierre Layrolle

Pages:

67-70

Citation:

I. Massie et al., "Synthesis and Phase Stability of Silicate-Substituted α-Tricalcium Phosphate", Key Engineering Materials, Vols. 361-363, pp. 67-70, 2008

Online since:

November 2007

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$38.00

[1] N. Patel, I.R. Gibson, K.A. Hing, S.M. Best, P.A. Revell and W. Bonfield J. Mater. Sci: Mater. Med. 13 (2002) 1199-1206.

[2] S. Langstaff, M. Sayer, T.J.N. Smith and S.M. Pugh. Biomaterials 22 (2001) 135-150.

[3] I.R. Gibson, S.M. Best and W. Bonfield J. Biomed. Mater. Res 44 (1999) 442-448.

[4] S. Langstaff, M. Sayer, T. Smith, S. Pugh, S. Hesp and W. Thompson. Biomaterials 20 (1999) 1727-1741.

[5] M. Sayer A.D. Stratilatov, J. Reid, L. Calderin, M.J. Stott, X. Yin, M. Mackenzie, T.J.N. Smith, J.A. Hendry and S.D. Langstaff. Biomaterials 24 (2003) 369-382.

DOI: https://doi.org/10.1016/s0142-9612(02)00327-7

[6] J.W. Reid, L. Tuck, M. Sayer, K. Fargo and J.A. Hendry. Biomaterials 27 (2006) 2916-2925.

[7] I.R. Gibson, I.U. Rehman, S.M. Best and W. Bonfield, J. Mat. Sci: Mater. Med. 11 (2000) 533539.

[8] A. Coelho, TOPAS-Academic V4, http: /members. optusnet. com. au/~alancoelho.

[9] J. Laugier and B. Bochu, CELREF V3 software, www. inpg. fr/LMGP Figure 3. Photoacoustic FTIR spectra of alpha-TCP (dashed line) and Si-alpha-TCP (solid line). Arrows indicate a shoulder on the phosphate peak for Si-alpha-TCP.