Three Dimensional Macroporous Calcium Phosphate Scaffolds for Bone Tissue Engineering
Calcium phosphate ceramics are widely used as bone substitutes since they are biocompatible and bioactive. Having a chemical composition close to natural bone, calcium phosphate ceramics are promising bone substitute materials in orthopaedics, maxillofacial surgery and dentistry. Hydroxyapatite (HA) and tricalcium phosphate (TCP) are the most commonly used calcium phosphates, because their calcium/phosphorus (Ca/P) ratios are close to that of natural bone and they are relatively stable in physiological environment. HA is a major constituent of bone materials and is resorbed after a long time of residence in the body. In this work, highly porous hydroxyapatite scaffolds were produced by polymer replication method and their properties evaluated by Scanning Electron Microscopy (SEM) and micro computerized tomography ()-CT).
Guy Daculsi and Pierre Layrolle
S. Teixeira et al., "Three Dimensional Macroporous Calcium Phosphate Scaffolds for Bone Tissue Engineering", Key Engineering Materials, Vols. 361-363, pp. 947-950, 2008