Biomimetic Smart Hydroxyapatite/Biphasic Tricalcium Phosphate Biomatrices Induce Bone Formation
Long-term studies in the non-human primate Papio ursinus were set to investigate the induction of bone formation in biphasic hydroxyapatite tricalcium phosphate (HA/TCP) biomimetic matrices, 20/80 and 40/60, respectively. Biomimetic matrices were implanted in the rectus abdominis and in calvarial defects of 4 adult Papio ursinus. Morphological analyses on day 90 and 365 showed significant induction of bone formation within concavities of the biomimetic matrices implanted in both heterotopic and orthotopic sites with resorption of the implanted biomimetic matrices. The smart biomimetic matrices induced de novo bone formation even in the absence of exogenously applied osteogenic proteins of the transforming growth factor-β superfamily.
Guy Daculsi and Pierre Layrolle
U. Ripamonti et al., "Biomimetic Smart Hydroxyapatite/Biphasic Tricalcium Phosphate Biomatrices Induce Bone Formation", Key Engineering Materials, Vols. 361-363, pp. 981-984, 2008