The Osteogenic Behaviour of Silicon Substituted Hydroxyapatite


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Dense and porous HA and Si-HA discs and granules with varying percentages of silicon substitution have been produced and physically and chemically characterised using scanning electron microscopy, surface area analysis, porosimetry, density measurement, image analysis, Xray diffraction, X-ray fluorescence, FT-infrared spectroscopy and in-vitro and in-vivo testing. Results have shown that cell adhesion in-vitro and bone apposition in-vivo are enhanced by the presence of silicon substitution in the hydroxyapatite structure. The biological response to the materials appears to indicate an optimum outcome for levels of silicon substitution of 0.8wt%.



Key Engineering Materials (Volumes 361-363)

Main Theme:

Edited by:

Guy Daculsi and Pierre Layrolle




S. Best et al., "The Osteogenic Behaviour of Silicon Substituted Hydroxyapatite", Key Engineering Materials, Vols. 361-363, pp. 985-988, 2008

Online since:

November 2007




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