Monitoring of Blood Flow by Drug Stimulation on Mouse Brain Using Non-Invasive Photoacoustic Imaging Technology


Article Preview

The highlight of photoacosutic imaging (PAI) is a method that combines ultrasonic resolution with high contrast due to light absorption. Photoacoustic signals carry the information of the light absorption distribution of biological tissue, which is often related to its character of structure, physiological and pathological changes because of different physiology conditions in response to different light absorption coefficients. A non-invasive PAI system was developed and successfully acquired in vivo images of mouse brain. Based on the intrinsic PA signals from the brain, the vascular network and the detailed structures of the mouse cerebral cortex were clearly visualized. The ability of PAI monitoring of cerebral hemodynamics was also demonstrated by mapping of the mouse superficial cortex with and without drug stimulation. The extracted PA signals intensity profiles obviously testified that the cerebral blood flow (CBF) in the mouse brain was changed under the stimulation of acetazolamide (ACZ). The experimental results suggest that PAI can provide non-invasive images of blood flow changes, and has the potential for brain function detection.



Key Engineering Materials (Volumes 364-366)

Edited by:

Guo Fan JIN, Wing Bun LEE, Chi Fai CHEUNG and Suet TO






S. H. Yang and Y. Q. Lao, "Monitoring of Blood Flow by Drug Stimulation on Mouse Brain Using Non-Invasive Photoacoustic Imaging Technology", Key Engineering Materials, Vols. 364-366, pp. 1123-1127, 2008

Online since:

December 2007




[1] Kruger R.A., Kiser W.L., Reinecke D.R. et al: Molecular. Imaging Vol. 2 (2003), p.113.

[2] Yi Wang, Da Xing, Yaguang Zeng et al: Phys. Med. Biol Vol. 49 (2004), p.3117.

[3] R. I. Siphanto, K. K. Thumma, R. G. M. Kolkman et al: Optics. Express Vol. 13 (2004), p.89.

[4] Yong Yao, Da Xing, Ken-ichi Ueda et al: J. Appl. Phys Vol. 94 (2003), p.1278.

[5] Lvming Zeng, Da Xing, Huaimin Gu et al: Chinese. Phys. Lett Vol. 23 (2006), p.1215.

[6] Yaguang Zeng, Da Xing, Yi Wang et al: Opt. Let Vol. 29 (2004), p.1760.

[7] Sihua Yang and Huaimin Gu: EPJ. Applied. Physics Vol. 37 (2006), p.87.

[8] Bangzheng Yin, Da Xing, Yi Wang et al: Phys. Med. Biol Vol. 49 (2004), p.1339.

[9] Diwu Yang, Da Xing, Huaimin Gu et al: Appl. Phys Vol. 87 (2005), p.194101.

[10] Diwu Yang, Da Xing, Yi Tan et al: Appl. Phys. Vol. 88 (2006), p.174101.

[11] Zhang H.F., Maslov K., Stoica G. et al: Nat. Biotechnol Vol. 24 (2006), p.848.

[12] Wang X., Xie X., Ku G. et al: J. Biomed. Opt Vol. 11 (2006), p.024015.

[13] S. Vorstrup, B. Brun, and N. A. Lassen: Stroke Vol. 17 (1986), p.1291.

[14] F. Chollet, P. Celsis, M. Clanet: Stroke Vol. 20 (1989), p.458.

[15] E. Hojer-Pedersen: Stroke Vol. 18 (1987), p.887.

In order to see related information, you need to Login.