Tissue Engineering Scaffolds of Bioceramics and New Bone Growth
The paper describes β-TCP/DCHA and mineral phase structural bioceramics(CHA) as well as their 3-D structures, bioactivity, degradability and introducing new bone growth. FT-IR, XRD, SEM and Micro-CT were used to evaluate β-TCP/DCHA and mineral phase structural ceramics before and after implantation. Osteoblasts were immersed in the bioceramics and implanted in the rabbit femora. The experimental results showed that new bone grown in β-TCP/DCHA, and scaffolds were degraded with new bone formation and growth. The results indicated that β-TCP/DCHA was a better tissue engineering material. A kind of biomaterial (β-TCP/CHA) can be used for in situ formation or in vitro individuation formation. The experimental results indicated that β-TCP/CHA possessed better osteoblast affinity. Osteoblasts can adhere, proliferate and grow better on the material. The experiments in vivo showed the materials bonded with osseous tissue. The implants were degraded obviously after 6 months, and new bone replaced degradation materials.
Wei Pan and Jianghong Gong
J. M. Tian et al., "Tissue Engineering Scaffolds of Bioceramics and New Bone Growth", Key Engineering Materials, Vols. 368-372, pp. 1161-1165, 2008